PMID- 7795891
OWN - NLM
STAT- MEDLINE
DCOM- 19950803
LR  - 20211203
IS  - 0960-5428 (Print)
IS  - 0960-5428 (Linking)
VI  - 5
IP  - 1
DP  - 1995
TI  - Narcolepsy and immunity.
PG  - 23-37
AB  - Narcolepsy is a neurological disorder known to be associated with human leukocyte 
      antigen (HLA)-DQB1*0602 in humans. In a canine model, the disorder is also 
      genetically linked to a gene of high homology with the human mu-switch-like 
      immunoglobulin (Ig) gene (current LOD score 13.6 at 0% recombination). Since 
      association with HLA or other immune function polymorphic genes (T cell receptor 
      of Ig, mainly) is a hallmark of most autoimmune diseases, it is proposed that 
      autoimmunity may also play a role in the development of narcolepsy. Arguments for 
      and against this hypothesis are reviewed. It is shown that both on the basis of 
      the most recent molecular studies, and because of some of its clinical features, 
      narcolepsy may be an autoimmune disorder. However, neither systemic nor central 
      nervous system (CNS) evidence of any autoimmune abnormality have ever been found. 
      To reconcile this discrepancy, it is suggested that the pathological immune 
      process involved in narcolepsy could be difficult to detect because it is 
      restricted to a very small region of the brain or targets a low abundance 
      neuroeffector. Alternatively, it is possible that a more fundamental relationship 
      is involved between sleep generation and immune regulation. The pathophysiology 
      of narcolepsy may then involve new CNS-immune mechanisms that may shed new light 
      on the sleep process itself.
FAU - Mignot, E
AU  - Mignot E
AD  - Stanford University Sleep Disorders Center, Palo Alto, CA 94304, USA.
FAU - Tafti, M
AU  - Tafti M
FAU - Dement, W C
AU  - Dement WC
FAU - Grumet, F C
AU  - Grumet FC
LA  - eng
GR  - NS/MH33797-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Adv Neuroimmunol
JT  - Advances in neuroimmunology
JID - 9108376
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR2 Antigen)
SB  - IM
GS  - DQ
GS  - DQA1
GS  - DQB1
GS  - DQB2
GS  - DQB3
GS  - DR
GS  - DRB1
GS  - HLA DQA1
GS  - HLA DQB1
GS  - canarc-1
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Autoimmune Diseases/genetics/immunology
MH  - Brain/immunology
MH  - Cattle
MH  - Chickens
MH  - Disease Models, Animal
MH  - Disease Susceptibility
MH  - Dog Diseases/genetics/immunology
MH  - Dogs
MH  - Ethnicity
MH  - Female
MH  - Genes, Immunoglobulin
MH  - Genes, Switch
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR2 Antigen/*genetics
MH  - Humans
MH  - Lod Score
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Narcolepsy/epidemiology/genetics/*immunology/veterinary
MH  - Rats
RF  - 116
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1016/0960-5428(94)00043-n [doi]
PST - ppublish
SO  - Adv Neuroimmunol. 1995;5(1):23-37. doi: 10.1016/0960-5428(94)00043-n.