PMID- 7796
OWN - NLM
STAT- MEDLINE
DCOM- 19761002
LR  - 20200108
VI  - 46
IP  - 2
DP  - 1976 Mar 16
TI  - Intracranial self-stimulation in rats as a function of various stimulus 
      parameters. VI. Influence of fentanyl, piritramide, and morphine on medial 
      forebrain bundle stimulation with monopolar electrodes.
PG  - 179-83
AB  - The effects of different subcutaneous doses of fentanyl (0.02, 0.04, 0.08, and 
      0.16 mg/kg), piritramide (0.63, 2.50, 10.0 and 40.0 mg/kg), and morphine (2.50, 
      5.00, 10.0 and 20.0 mg/kg) on self-stimulation in rats were studied. Different 
      stimulus parameter combinations (SPC) inducing low, high or intermediate control 
      response rates (CRR) were applied during the same experimental sessions. The 
      three narcotic analgesics induced response depression (RD) and response 
      stimulation (RS). RS was mostly observed at low dose levels; RD was dose-related. 
      SPC's inducing low CRR were more sensitive than those inducing high CRR. Fentanyl 
      was more potent than piritramide and than morphine. The RD is related to motor 
      incapacitation, as the doses needed to effectively reduce self-stimulation also 
      induced obvious catatonia. The RS probably is a more specific effect reflecting 
      sensitization of structures involved in reinforcement of behavior.
FAU - Wauquier, A
AU  - Wauquier A
FAU - Niemegeers, C J
AU  - Niemegeers CJ
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Psychopharmacologia
JT  - Psychopharmacologia
JID - 7609417
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Isonipecotic Acids)
RN  - 0 (Piperidines)
RN  - 76I7G6D29C (Morphine)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Analgesics, Opioid/*pharmacology
MH  - Animals
MH  - Catatonia/chemically induced
MH  - Fentanyl/*pharmacology
MH  - Humans
MH  - Hypothalamus/physiology
MH  - Isonipecotic Acids/*pharmacology
MH  - Male
MH  - Morphine/*pharmacology
MH  - Piperidines/pharmacology
MH  - Rats
MH  - Reinforcement, Psychology
MH  - Self Stimulation/*drug effects
EDAT- 1976/03/16 00:00
MHDA- 1976/03/16 00:01
CRDT- 1976/03/16 00:00
PHST- 1976/03/16 00:00 [pubmed]
PHST- 1976/03/16 00:01 [medline]
PHST- 1976/03/16 00:00 [entrez]
AID - 10.1007/BF00421389 [doi]
PST - ppublish
SO  - Psychopharmacologia. 1976 Mar 16;46(2):179-83. doi: 10.1007/BF00421389.