PMID- 7798612
OWN - NLM
STAT- MEDLINE
DCOM- 19950124
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 103
IP  - 6
DP  - 1994 Dec
TI  - Human leukocyte antigen-DQB1*03 alleles are associated with alopecia areata.
PG  - 758-63
AB  - Alopecia areata (AA) is characterized by hair loss in patches (patchy AA), over 
      the entire scalp (AT, totalis), or universally (AU). An autoimmune mechanism has 
      been hypothesized, because the inflammatory infiltrate targeted to the hair 
      follicles includes activated T cells. To investigate whether or not genetic 
      polymorphism of the human leukocyte antigen (HLA) region contributes to disease 
      susceptibility, we used sequence-specific oligonucleotides and amplified genomic 
      DNA to define HLA-DQA1, -DQB1, and -DPB1 alleles in a cohort of 85 white 
      patients. The frequency of DQB1*0301 was significantly increased to 41% in all 
      patients, and to 47% in AT/AU patients relative to controls (27%). Analyzed 
      together, DQB1*03 alleles (DQB1*0301-*0303) were increased to 80% (all patients) 
      and to 92% (AT/AU) (odds ratio = 12.14, p = 0.00003, corrected). This striking 
      association implicates the DQB1*03 alleles in the pathogenesis of AA. DQB1*06 was 
      decreased relative to controls (56%) in all patients (32%, odds ratio = 0.37, p = 
      0.0045, corrected). An increase was observed in the HLA-DRB1*11(DR5) allele 
      DRB1*1104, which may result from linkage disequilibrium with DQB1 alleles. 
      Sequence comparison among the allele products associated with AA indicates that 
      the DQB1*03 alleles carry a unique proline at position 55 that is not present in 
      alleles that are neutral or negatively associated with the disease. This highly 
      significant association may exert considerable control over immune responsiveness 
      and the initiation or persistence of a T-cell autoimmune response against the 
      hair follicle.
FAU - Welsh, E A
AU  - Welsh EA
AD  - Department of Dermatology, University of Texas Medical School at Houston 77030.
FAU - Clark, H H
AU  - Clark HH
FAU - Epstein, S Z
AU  - Epstein SZ
FAU - Reveille, J D
AU  - Reveille JD
FAU - Duvic, M
AU  - Duvic M
LA  - eng
GR  - AR39915/AR/NIAMS NIH HHS/United States
GR  - AR40520/AR/NIAMS NIH HHS/United States
GR  - RD36546/RD/ORD VA/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Alleles
MH  - Alopecia Areata/*immunology
MH  - Base Sequence
MH  - Gene Amplification
MH  - Gene Frequency
MH  - HLA-DP Antigens/genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - S0022-202X(94)95816-5 [pii]
AID - 10.1111/1523-1747.ep12412584 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1994 Dec;103(6):758-63. doi: 10.1111/1523-1747.ep12412584.