PMID- 7799981
OWN - NLM
STAT- MEDLINE
DCOM- 19950123
LR  - 20131121
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 18
IP  - 1
DP  - 1995 Jan
TI  - Influence of baclofen upon the alpha-motoneuron in spasticity by means of F-wave 
      analysis.
PG  - 103-7
AB  - Intrathecal baclofen dramatically improves severe spastic syndromes. This 
      improvement is likely related to reduced excitability of alpha-motoneurons. To 
      investigate the influence of baclofen upon the alpha-motoneuron, we analyzed 
      F-waves before and after intrathecal baclofen bolus injection (usually 50 
      micrograms) as well as after administration of different, constantly delivered 
      doses (60-200 micrograms/day). Intrathecal baclofen bolus decreased the maximum 
      F-wave amplitude (Fp) from an initial value of 9% of the maximum M amplitude 
      (Mmax) (= F/M-ratio) to 2.4% of the Mmax after 130-180 min, reduced the mean 
      F-wave amplitude 60% within 150 min, and shortened the mean duration by 40-60% 
      after 130-180 min. Constantly delivered baclofen of 100 micrograms/day reduced 
      the F/M-ratio from 5% to 2%, the mean F-wave amplitude by 40-80%, and the F-wave 
      mean duration by 40-80%. The minimum F-wave latency did not change after bolus or 
      during steady state administration. The findings indicate that the F-wave mean 
      and maximum amplitude as well as the mean duration are altered in a quantifiable 
      manner following intrathecal baclofen application.
FAU - Dressnandt, J
AU  - Dressnandt J
AD  - Neurologic Department, Technical University, Munich, Germany.
FAU - Auer, C
AU  - Auer C
FAU - Conrad, B
AU  - Conrad B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - H789N3FKE8 (Baclofen)
SB  - IM
MH  - Baclofen/*pharmacology
MH  - Electrophysiology
MH  - Humans
MH  - Infusion Pumps
MH  - Injections, Spinal
MH  - Motor Neurons/*drug effects
MH  - Muscle Spasticity/*physiopathology
MH  - Reaction Time
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1002/mus.880180114 [doi]
PST - ppublish
SO  - Muscle Nerve. 1995 Jan;18(1):103-7. doi: 10.1002/mus.880180114.