PMID- 7801890
OWN - NLM
STAT- MEDLINE
DCOM- 19950123
LR  - 20190512
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 102
IP  - 6
DP  - 1994 Dec
TI  - Fluorescence in situ hybridization analysis of trisomy 12 in ovarian tumors.
PG  - 775-9
AB  - Conventional cytogenetic studies have suggested that trisomy 12 may be a 
      characteristic nonrandom numerical chromosome anomaly in benign ovarian tumors, 
      particularly sex cord-stromal tumors. To confirm this finding, and to avoid 
      possible culture artifact introduced during cytogenetic analysis, the authors 
      performed fluorescence in situ hybridization (FISH) in paraffin-embedded samples 
      of select ovarian neoplasms. Forty-four ovarian fibromas and granulosa cell 
      tumors and 31 benign and borderline epithelial ovarian tumors were examined for 
      the presence of trisomy 12. Trisomy 12 was detected in 40% (8 of 20) of the 
      fibromas. No evidence of trisomy 12 was present in 24 granulosa cell tumors, 
      although 1 granulosa cell tumor was tetrasomic for chromosome 12. Trisomy 12 was 
      found in 27% (3 of 11) of the serous borderline tumors, but was not observed in 
      any of the benign epithelial tumors (13 serous and 7 mucinous cystadenomas). 
      These results confirm that trisomy 12 occurs in a significant proportion of 
      fibromas. However, the incidence of trisomy 12 in granulosa cell tumors is far 
      lower than suggested by previous studies. These results, in conjunction with 
      those of previous cytogenetic reports, suggest that trisomy 12 is rare in benign 
      epithelial ovarian tumors, but occurs fairly commonly as a sole anomaly in 
      borderline epithelial tumors. Further investigation is necessary to establish the 
      significance of trisomy 12 in the pathogenesis of these tumors.
FAU - Persons, D L
AU  - Persons DL
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, 
      Rochester, MN 55905.
FAU - Hartmann, L C
AU  - Hartmann LC
FAU - Herath, J F
AU  - Herath JF
FAU - Keeney, G L
AU  - Keeney GL
FAU - Jenkins, R B
AU  - Jenkins RB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Female
MH  - Fibroma/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Neoplasms, Glandular and Epithelial/*genetics
MH  - Ovarian Neoplasms/*genetics
MH  - *Trisomy
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.1093/ajcp/102.6.775 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 1994 Dec;102(6):775-9. doi: 10.1093/ajcp/102.6.775.