PMID- 780285
OWN - NLM
STAT- MEDLINE
DCOM- 19761001
LR  - 20211203
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 18
IP  - 1
DP  - 1976 Jul 15
TI  - Selective suppression of T-cell activity in tumor-bearing mice and its 
      improvement by lentinan, a potent anti-tumor polysaccharide.
PG  - 93-104
AB  - The cellular site of immunosuppression in Ehrlich tumor-bearing mice was analysed 
      with particular reference to the T- and B-cell activities. The B-cell activity as 
      measured by the anti-dinitrophenyl (DNP) antibody responses to 
      DNP-thymus-independent carriers (TID) was not impaired in tumor-bearing mice as 
      compared with normal mice, whereas the anti-DNP antibody response to 
      DNP-thymus-dependent carriers (TD) and the development of helper T-cell activity 
      to TD were markedly suppressed in tumor-bearing animals or mice pretreated with 
      cell-free cancerous ascitic fluid. The selective suppression of T-cell response 
      was not mediated by the generation of suppressor cell activity toward TD, which 
      may depress the manifestation of developed helper T-cell activity. A marked 
      suppression of T-cell response was observed when the animals were inoculated with 
      tumor cells or injected with cancerous ascitic fluid prior to antigenic 
      stimulation, but not when the animals were rendered tumor-bearing by such 
      treatments after the immunization. The suppression of T-cell activity in both 
      sarcoma 180 tumor-bearing mice and cell-free Ehrlich cancerous ascitic 
      fluid-treated mice was prevented by treatment with lentinan, a potent anti-tumor 
      polysaccharide. The applicability of this experimental system to the search for 
      immunopotentiators relevant to tumor immunotherapy is discussed in the light of 
      the preventive effect of lentinan on the suppression of T-cell response in 
      tumor-bearing animals.
FAU - Haba, S
AU  - Haba S
FAU - Hamaoka, T
AU  - Hamaoka T
FAU - Takatsu, K
AU  - Takatsu K
FAU - Kitagawa, M
AU  - Kitagawa M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antibodies, Neoplasm)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Haptens)
RN  - 0 (Polysaccharides)
RN  - 37339-90-5 (Lentinan)
SB  - IM
MH  - Animals
MH  - Antibodies, Neoplasm
MH  - Antigen-Antibody Reactions
MH  - Antigens, Bacterial
MH  - Antigens, Neoplasm
MH  - B-Lymphocytes/drug effects/immunology
MH  - Carcinoma, Ehrlich Tumor/*immunology
MH  - Haptens
MH  - Hemolytic Plaque Technique
MH  - Immunoassay
MH  - *Immunosuppression Therapy
MH  - Lentinan/*pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Polysaccharides/*pharmacology
MH  - Sarcoma, Experimental/*immunology
MH  - T-Lymphocytes/drug effects/*immunology
MH  - Time Factors
EDAT- 1976/07/15 00:00
MHDA- 1976/07/15 00:01
CRDT- 1976/07/15 00:00
PHST- 1976/07/15 00:00 [pubmed]
PHST- 1976/07/15 00:01 [medline]
PHST- 1976/07/15 00:00 [entrez]
AID - 10.1002/ijc.2910180113 [doi]
PST - ppublish
SO  - Int J Cancer. 1976 Jul 15;18(1):93-104. doi: 10.1002/ijc.2910180113.