PMID- 7805247
OWN - NLM
STAT- MEDLINE
DCOM- 19950201
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 91
IP  - 2
DP  - 1995 Jan 15
TI  - Effect of left ventricular hypertrophy and its regression on ventricular 
      electrophysiology and vulnerability to inducible arrhythmia in the feline heart.
PG  - 426-30
AB  - BACKGROUND: Left ventricular hypertrophy (LVH) is associated with an increased 
      risk of death, susceptibility to ventricular arrhythmia, and multiple 
      electrophysiological abnormalities. The purpose of the present study was to 
      determine whether the susceptibility to arrhythmia and electrical abnormalities 
      persists after regression of hypertrophy in an animal model of LVH. METHODS AND 
      RESULTS: We placed constricting bands on the ascending aorta of cats (n = 9) or 
      performed sham operations (n = 9). Serial cardiac echocardiography was performed 
      to measure left ventricular wall thickness. After LVH had developed in the banded 
      animals, the constricting bands were removed and serial echocardiograms were used 
      to monitor for regression of hypertrophy. Electrophysiological studies were 
      performed in cats that showed regression of LVH (Regress, n = 5), those that 
      showed no change in LV wall thickness (No Regress, n = 4), and in the 
      sham-operated animals (Sham). Cats with persistent LVH had a higher incidence of 
      inducible polymorphic ventricular tachycardia (4 of 4) compared with Regress (1 
      of 5) or Sham (1 of 9) cats (P < .05) and had lower ventricular fibrillation 
      thresholds (9 +/- 2 mA) than Regress (17 +/- 4 mA) or Sham (16 +/- 3 mA) cats (P 
      < .05). Persistent LVH in the No Regress group was associated with prolongation 
      of epicardial monophasic action potential duration (MAPD) in the left but not the 
      right ventricle. Dispersion of refractoriness was greater in the No Regress group 
      (P < .05 versus Regress or Sham). Regress cats were identical to Sham cats in 
      having a low incidence of inducible polymorphic ventricular arrhythmia, high 
      fibrillation threshold, and MAPD measurements (P = NS versus Sham). CONCLUSIONS: 
      LVH produces multiple electrophysiological abnormalities and increased 
      vulnerability to inducible polymorphic ventricular arrhythmia in this model of 
      LVH. Cats that show regression of hyperthrophy have normal ventricular 
      electrophysiology and have the same low vulnerability to inducible ventricular 
      arrhythmia as Sham animals.
FAU - Rials, S J
AU  - Rials SJ
AD  - Cardiovascular Division, Lankenau Hospital and Medical Research Center, 
      Wynnewood, Pa.
FAU - Wu, Y
AU  - Wu Y
FAU - Ford, N
AU  - Ford N
FAU - Pauletto, F J
AU  - Pauletto FJ
FAU - Abramson, S V
AU  - Abramson SV
FAU - Rubin, A M
AU  - Rubin AM
FAU - Marinchak, R A
AU  - Marinchak RA
FAU - Kowey, P R
AU  - Kowey PR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Arrhythmias, Cardiac/*etiology
MH  - Cats
MH  - Echocardiography
MH  - Electrophysiology
MH  - Female
MH  - Heart/*physiology
MH  - Hypertrophy, Left Ventricular/diagnostic imaging/*physiopathology
MH  - Male
MH  - Tachycardia, Ventricular/etiology
MH  - Ventricular Fibrillation/diagnosis/etiology
MH  - Ventricular Function
EDAT- 1995/01/15 00:00
MHDA- 1995/01/15 00:01
CRDT- 1995/01/15 00:00
PHST- 1995/01/15 00:00 [pubmed]
PHST- 1995/01/15 00:01 [medline]
PHST- 1995/01/15 00:00 [entrez]
AID - 10.1161/01.cir.91.2.426 [doi]
PST - ppublish
SO  - Circulation. 1995 Jan 15;91(2):426-30. doi: 10.1161/01.cir.91.2.426.