PMID- 7805752
OWN - NLM
STAT- MEDLINE
DCOM- 19950127
LR  - 20220310
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 24
IP  - 12
DP  - 1994 Dec
TI  - Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 
      and -3.
PG  - 3233-6
AB  - Under certain physiological and pathological conditions, natural killer (NK) 
      cells rapidly accumulate in tissues. Chemokines are an essential component of the 
      current paradigm of leukocyte recruitment. The present study was designed to 
      investigate the responsiveness of NK cells to the prototypic C-C chemokine, 
      monocyte chemotactic protein-1 (MCP-1). MCP-1 induced migration across filters of 
      interleukin (IL)-2-activated NK cells, whereas it was a weak attractant for 
      unstimulated cells. Maximal induction of migration required a positive 
      concentration gradient between the lower and the upper compartment of the 
      chemotaxis chamber. Preliminary characterization of the MCP-1 receptor on NK 
      cells indicated that the chemotactic response to MCP-1 was blocked by 
      pre-treatment of cells with Bordetella pertussis toxin, and MCP-1 but not IL-8 
      displaced 125I-labeled MCP-1 from IL-2-activated NK cells. The related chemokines 
      MCP-2 and MCP-3 were also active--though less potent--attractants for activated 
      NK cells. Thus the spectrum of action of MCP-1, -2 and -3 encompasses NK cells 
      and chemokines are likely to play a role in regulating extravasation of these 
      cells.
FAU - Allavena, P
AU  - Allavena P
AD  - Laboratory of Immunology, Istituto Mario Negri, Milano, Italy.
FAU - Bianchi, G
AU  - Bianchi G
FAU - Zhou, D
AU  - Zhou D
FAU - van Damme, J
AU  - van Damme J
FAU - Jilek, P
AU  - Jilek P
FAU - Sozzani, S
AU  - Sozzani S
FAU - Mantovani, A
AU  - Mantovani A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (CCL7 protein, human)
RN  - 0 (CCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL7)
RN  - 0 (Chemokine CCL8)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (Monocyte Chemoattractant Proteins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Binding, Competitive
MH  - Chemokine CCL2
MH  - Chemokine CCL7
MH  - Chemokine CCL8
MH  - Chemotactic Factors/*pharmacology
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - *Cytokines
MH  - Humans
MH  - In Vitro Techniques
MH  - Killer Cells, Natural/*cytology
MH  - Lymphocyte Activation
MH  - *Monocyte Chemoattractant Proteins
MH  - Receptors, Cell Surface/metabolism
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.1002/eji.1830241249 [doi]
PST - ppublish
SO  - Eur J Immunol. 1994 Dec;24(12):3233-6. doi: 10.1002/eji.1830241249.