PMID- 7811864
OWN - NLM
STAT- MEDLINE
DCOM- 19950203
LR  - 20190512
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 19
IP  - 3
DP  - 1994 Sep
TI  - Simultaneous measurement of antibodies to Epstein-Barr virus, human herpesvirus 
      6, herpes simplex virus types 1 and 2, and 14 enteroviruses in chronic fatigue 
      syndrome: is there evidence of activation of a nonspecific polyclonal immune 
      response?
PG  - 448-53
AB  - As a test of the hypothesis that elevated titers of viral antibodies in patients 
      with chronic fatigue syndrome (CFS) are due to a nonspecific polyclonal immune 
      response, antibodies to Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), 
      and 14 enteroviruses in 20 patients with CFS and 20 age- and gender-matched 
      controls were simultaneously measured. Similarly, titers of IgG to herpes simplex 
      virus (HSV) types 1 and 2 were measured in 18 of these cases and in the 
      respective controls. IgG to EBV viral capsid antigen (VCA) was present at titers 
      > or = 1:320 in 55% of cases vs. 15% of controls (P = .02). The geometric mean 
      titers of early antigen antibody to EBV, HHV-6 IgG, and HSV-1 and HSV-2 IgG were 
      not significantly different among cases and controls. Of the 14 enteroviral 
      antibodies tested for, only those to coxsackieviruses B1 and B4 were present at 
      significant titers (> or = 1:8) in cases vs. controls (P = .02 and P = .001, 
      respectively). Of the cases, 19 (95%) had either an EBV VCA IgG titer > or = 
      1:320 or a coxsackievirus B1 or B4 antibody titer > or = 1:8, a percentage 
      significantly higher than that of controls (40%; P = .0004). Titers of EBV VCA 
      IgG and coxsackievirus B1 and B4 antibodies were simultaneously elevated in only 
      20% of cases. There was no correlation between elevated titers of EBV VCA IgG and 
      IgG to HHV-6, HSV-1, and HSV-2 or antibody to coxsackieviruses B1 and B4 in the 
      cases. The prevalence of reported allergies to medications or other substances 
      was identical in both groups (60%). These findings suggest that in the majority 
      of cases of CFS, elevation of viral antibody titers is not due to a nonspecific 
      polyclonal immune response.
FAU - Manian, F A
AU  - Manian FA
AD  - Division of Infectious Diseases, St. John's Mercy Medical Center, St. Louis, 
      Missouri.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
CIN - Clin Infect Dis. 1995 Sep;21(3):708-9. PMID: 8527589
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/*blood
MH  - Enterovirus/immunology
MH  - Fatigue Syndrome, Chronic/blood/*immunology
MH  - Female
MH  - Herpesvirus 1, Human/*immunology
MH  - Herpesvirus 2, Human/*immunology
MH  - Herpesvirus 4, Human/*immunology
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Immunoglobulin G/*blood
MH  - Male
MH  - Middle Aged
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1093/clinids/19.3.448 [doi]
PST - ppublish
SO  - Clin Infect Dis. 1994 Sep;19(3):448-53. doi: 10.1093/clinids/19.3.448.