PMID- 7812784
OWN - NLM
STAT- MEDLINE
DCOM- 19950206
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 655
IP  - 1-2
DP  - 1994 Aug 29
TI  - CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal 
      effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine 
      (MDMA).
PG  - 259-62
AB  - We have used female and male transgenic (Tg) mice that carry the complete 
      sequence of the human copper-zinc (CuZn) superoxide dismutase (SOD) gene in order 
      to assess the lethal effects of methylenedioxyamphetamine (MDA) and 
      methylenedioxymethamphetamine (MDMA). In contrast to non-Tg mice, both 
      heterozygous and homozygous SOD-Tg mice showed resistance to the lethal effects 
      of both drugs. Females of both SOD-Tg and non-Tg strains were somewhat more 
      resistant to the effects of these drugs in comparison to males. In general, 
      homozygous animals show greater resistance to the effects of the two drugs. These 
      results suggest that the acute lethal effects of amphetamine-substituted analogs 
      might involve the intracellular overproduction of the superoxide radicals 
      secondary to hypoxic injury. The gender differences suggest that there might be 
      hormonal-free radical scavenger interactions that offer better protection to 
      female mice. This might be related both to the lifespan of and to the lower 
      prevalence of Parkinson's disease in women. Future studies will need to address 
      these issues further.
FAU - Cadet, J L
AU  - Cadet JL
AD  - Molecular Neuropsychiatry Section, NIH/NIDA, Addiction Research Center, 
      Baltimore, MD 21224.
FAU - Ladenheim, B
AU  - Ladenheim B
FAU - Baum, I
AU  - Baum I
FAU - Carlson, E
AU  - Carlson E
FAU - Epstein, C
AU  - Epstein C
LA  - eng
GR  - AG-08938/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 11062-77-4 (Superoxides)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Animals
MH  - Female
MH  - Humans
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Oxygen Consumption/drug effects
MH  - Sex Characteristics
MH  - Superoxide Dismutase/*genetics
MH  - Superoxides/metabolism
EDAT- 1994/08/29 00:00
MHDA- 1994/08/29 00:01
CRDT- 1994/08/29 00:00
PHST- 1994/08/29 00:00 [pubmed]
PHST- 1994/08/29 00:01 [medline]
PHST- 1994/08/29 00:00 [entrez]
AID - 0006-8993(94)91624-1 [pii]
AID - 10.1016/0006-8993(94)91624-1 [doi]
PST - ppublish
SO  - Brain Res. 1994 Aug 29;655(1-2):259-62. doi: 10.1016/0006-8993(94)91624-1.