PMID- 7812922
OWN - NLM
STAT- MEDLINE
DCOM- 19950203
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 75
IP  - 2
DP  - 1995 Jan 15
TI  - Association of human leukocyte antigen-B1*03 with cervical cancer in Japanese 
      women aged 35 years and younger.
PG  - 518-21
AB  - BACKGROUND: An association of human leukocyte antigen (HLA)-DQw3 alleles with 
      squamous cell carcinoma (SCC) of the cervix has been reported in some European 
      populations, but the significance of HLA-DQw3 has not been examined in other 
      populations to the authors' knowledge. The interaction between HLA-DQw3 and human 
      papillomavirus (HPV) in SCC remains to be clarified. METHODS: To elucidate the 
      association of HLA-DQ alleles with SCC of the cervix, DNA samples extracted from 
      blood lymphocytes of 23 patients with SCC were amplified by the polymerase chain 
      reaction (PCR) using specific primers for the DQB1 genes, and then, each HLA-DQB1 
      genotype was defined by digestion with restriction enzymes. Human papillomavirus 
      typing also was performed in all cases by PCR, using specific primers for the E6 
      regions of cancer-associated HPV types (HPV 16, 18 and 33). RESULTS: Twenty 
      patients (87%) carried a DQB1 gene-encoding HLA-DQw3, compared with 49.4% 
      Japanese control subjects in the International Histocompatibility Workshop panel 
      (P = 0.0003). Human papillomavirus 16 or HPV 18 DNA was detected in 86% of the 
      patients. In 13 of the patients with invasive carcinoma with HPV, a high 
      incidence of not only HLA-DQw3 but also of HLA-DQw1 was observed compared with 
      that in control subjects (P = 0.0019, P = 0.047, respectively). The correlation 
      between DQB1*03 alleles and HPV infection was not statistically significant. 
      CONCLUSION: The frequency of HLA-DQw3 alleles was higher in the authors' patient 
      group than in the control group, suggesting that the HLA-DQw3 molecules may 
      influence the development of SCC of the cervix in young Japanese women. In the 
      patients with HPV-positive invasive carcinoma, the association with HLA-DQw1 
      molecules suggested that it also may influence the progression of SCC.
FAU - Nawa, A
AU  - Nawa A
AD  - Department of Obstetrics and Gynecology.
FAU - Nishiyama, Y
AU  - Nishiyama Y
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Wakahara, Y
AU  - Wakahara Y
FAU - Okamoto, T
AU  - Okamoto T
FAU - Kikkawa, F
AU  - Kikkawa F
FAU - Suganuma, N
AU  - Suganuma N
FAU - Goto, S
AU  - Goto S
FAU - Kuzuya, K
AU  - Kuzuya K
FAU - Tomoda, Y
AU  - Tomoda Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adult
MH  - Carcinoma, Squamous Cell/*immunology/virology
MH  - Disease Progression
MH  - Female
MH  - HLA-DQ Antigens/*analysis
MH  - Humans
MH  - Japan
MH  - Papillomaviridae/isolation & purification
MH  - Polymerase Chain Reaction
MH  - Uterine Cervical Neoplasms/*immunology/virology
EDAT- 1995/01/15 00:00
MHDA- 1995/01/15 00:01
CRDT- 1995/01/15 00:00
PHST- 1995/01/15 00:00 [pubmed]
PHST- 1995/01/15 00:01 [medline]
PHST- 1995/01/15 00:00 [entrez]
AID - 10.1002/1097-0142(19950115)75:2<518::aid-cncr2820750214>3.0.co;2-i [doi]
PST - ppublish
SO  - Cancer. 1995 Jan 15;75(2):518-21. doi: 
      10.1002/1097-0142(19950115)75:2<518::aid-cncr2820750214>3.0.co;2-i.