PMID- 7813807
OWN - NLM
STAT- MEDLINE
DCOM- 19950207
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 44
IP  - 1
DP  - 1995 Jan
TI  - The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 
      6 and 11 disease susceptibility genes.
PG  - 132-6
AB  - Type I diabetes susceptibility genes have been identified within the major 
      histocompatibility complex (MHC) on chromosome 6p21.3 and near the VNTR/insulin 
      region on chromosome 11p15.5. We have used polymorphic dinucleotide repeat 
      markers to search the human genome for additional susceptibility genes in 162 
      type I diabetic families with an affected sibling pair. We report that an 
      additional susceptibility gene is located on chromosome 2q31 near HOXD8 (P < 
      10(-5), maximum logarithm of odds score = 4.8) in an analysis of affected sibling 
      pairs having specific human leukocyte antigen (HLA) and hypervariable nucleotide 
      tandem repeat (VNTR)/insulin gene haplotypes (absence of high-risk HLA-DR3/4 
      haplotypes and presence of homozygous high-risk class I VNTR alleles). These 
      results suggest the interaction of a minimum of three genes in the pathogenesis 
      of type I diabetes in humans.
FAU - Owerbach, D
AU  - Owerbach D
AD  - Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
FAU - Gabbay, K H
AU  - Gabbay KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
SB  - IM
GS  - HOXD8
MH  - Alleles
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 6
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Family Health
MH  - Genes, Homeobox/*genetics
MH  - *Genetic Linkage
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.2337/diab.44.1.132 [doi]
PST - ppublish
SO  - Diabetes. 1995 Jan;44(1):132-6. doi: 10.2337/diab.44.1.132.