PMID- 7816211
OWN - NLM
STAT- MEDLINE
DCOM- 19950209
LR  - 20190712
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 62
IP  - 1
DP  - 1994 Sep
TI  - Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and 
      increases extracellular levels of dopamine and serotonin in the nucleus accumbens 
      in vivo.
PG  - 41-50
AB  - The nucleus accumbens has been implicated as an important site for the actions of 
      many drugs that are used recreationally. This study examined the effects of 
      methylenedioxymethamphetamine (MDMA), a euphoric and hallucinogenic drug, on 
      glutamate-evoked neuronal firing and on extracellular levels of dopamine and 
      serotonin in the nucleus accumbens of the rat. Microiontophoretic application of 
      MDMA inhibited glutamate-evoked firing of most of the nucleus accumbens cells 
      that were tested (83 of 86), as did microiontophoretic application of dopamine 
      and serotonin. MDMA-induced inhibition of glutamate-evoked firing was partially 
      blocked by the dopamine antagonist SCH39166 and was attenuated by combined 
      pretreatment with inhibitors of both serotonin and catecholamine synthesis, 
      p-chlorophenylalanine and alpha-methyl-p-tyrosine. MDMA applied directly into the 
      nucleus accumbens and adjacent regions of the ventral striatum through a dialysis 
      probe increased extracellular levels of both dopamine and serotonin. These 
      results indicate that MDMA has inhibitory effects on glutamate-evoked neuronal 
      firing in the nucleus accumbens and suggest that the inhibition is mediated by 
      increased extracellular dopamine and serotonin. Furthermore, these results permit 
      MDMA to be added to the extensive list of abused drugs that have been 
      demonstrated to elevate extracellular levels of dopamine and serotonin in the 
      nucleus accumbens.
FAU - White, S R
AU  - White SR
AD  - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, 
      Washington State University, Pullman 99164.
FAU - Duffy, P
AU  - Duffy P
FAU - Kalivas, P W
AU  - Kalivas PW
LA  - eng
GR  - DA-03906/DA/NIDA NIH HHS/United States
GR  - DA-08116/DA/NIDA NIH HHS/United States
GR  - MH-40817/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 333DO1RDJY (Serotonin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Dopamine/*metabolism
MH  - Electrophysiology
MH  - Extracellular Space/*metabolism
MH  - Glutamic Acid/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neurons/drug effects/physiology
MH  - Nucleus Accumbens/cytology/drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 0306-4522(94)90313-1 [pii]
AID - 10.1016/0306-4522(94)90313-1 [doi]
PST - ppublish
SO  - Neuroscience. 1994 Sep;62(1):41-50. doi: 10.1016/0306-4522(94)90313-1.