PMID- 7817966
OWN - NLM
STAT- MEDLINE
DCOM- 19950209
LR  - 20190512
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 141
IP  - 2
DP  - 1995 Jan 15
TI  - Damp housing and childhood respiratory symptoms: the role of sensitization to 
      dust mites and molds.
PG  - 103-10
AB  - In 1990, a case-control study was conducted in the Netherlands into the 
      association between damp housing, childhood respiratory symptoms, and 
      sensitization to house dust mites and mold allergens. In this study, 259 children 
      with chronic respiratory symptoms and 257 control children were involved. Total 
      serum immunoglobulin E (IgE) and specific IgE against house dust mites and a 
      mixture of molds were determined. A visual inspection for signs of home dampness 
      was performed in all homes. A questionnaire was given to the parents of the 
      children to elicit information about the presence of signs of dampness in the 
      previous 2 years and about risk factors for childhood respiratory disease. In the 
      case group, 94 children had elevated serum IgE levels to house dust mites and 24 
      children to the mixture of molds. In the control group, house dust mite allergy 
      was found in 31 children and mold allergy in two children. In a crude analysis, 
      cases were slightly more likely to have been living in homes where damp or mold 
      was reported or observed than were the controls. In cases as well as controls, 
      home dampness was associated with increased sensitization to dust mites and 
      molds. There was no relation between home dampness and case-control status after 
      stratification for sensitization, however. Restriction of the analysis to cases 
      with elevated serum IgE levels against dust mites and/or molds, and to controls 
      without elevated serum IgE, increased the odds ratios, and several became 
      significant at p < 0.05. This supports a connection between damp housing and 
      sensitization to dust mites and/or molds and childhood respiratory 
      symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Verhoeff, A P
AU  - Verhoeff AP
AD  - Municipal Health Service, Department of Environmental Medicine, Amsterdam, The 
      Netherlands.
FAU - van Strien, R T
AU  - van Strien RT
FAU - van Wijnen, J H
AU  - van Wijnen JH
FAU - Brunekreef, B
AU  - Brunekreef B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (Allergens)
RN  - 0 (Dust)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/adverse effects/*immunology
MH  - Animals
MH  - Case-Control Studies
MH  - Child
MH  - Chronic Disease
MH  - Dust
MH  - Female
MH  - Fungi/*immunology
MH  - Housing
MH  - Humans
MH  - Humidity/*adverse effects
MH  - Hypersensitivity, Immediate/etiology/*immunology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mites/*immunology
MH  - Respiratory Mechanics
MH  - Respiratory Sounds/immunology
MH  - Respiratory Tract Diseases/etiology/*immunology
EDAT- 1995/01/15 00:00
MHDA- 1995/01/15 00:01
CRDT- 1995/01/15 00:00
PHST- 1995/01/15 00:00 [pubmed]
PHST- 1995/01/15 00:01 [medline]
PHST- 1995/01/15 00:00 [entrez]
AID - 10.1093/oxfordjournals.aje.a117398 [doi]
PST - ppublish
SO  - Am J Epidemiol. 1995 Jan 15;141(2):103-10. doi: 
      10.1093/oxfordjournals.aje.a117398.