PMID- 7820657
OWN - NLM
STAT- MEDLINE
DCOM- 19950213
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 659
IP  - 1-2
DP  - 1994 Oct 3
TI  - Regional suppression by water intake of c-fos expression induced by 
      intraventricular infusions of angiotensin II.
PG  - 157-68
AB  - Intracerebroventricular (i.c.v.) infusions of angiotensin II (AII) reliably 
      induced c-fos expression in the supraoptic (SON) and paraventricular (PVN) 
      nuclei, as well as other areas of the basal forebrain including the OVLT, 
      subfornical organ (SFO), and bed nucleus (BNST). Double-labelling showed that 
      AII-induced c-fos was observed in both vasopressin (AVP-) and oxytocin 
      (OXY)-containing neurons of the SON and PVN in male rats. Allowing rats to drink 
      water after AII infusions suppressed c-fos expression both AVP- and OXY-stained 
      magnocellular neurons. Intragastric infusions of water were also effective, 
      showing that oro-pharyngeal stimuli were not critical. Maximal suppression 
      occurred in rats in whom water had been infused intragastrically about 5 min 
      before i.c.v. AII infusions, suggesting that changes in osmolarity were 
      responsible. i.c.v. AII also induced c-fos expression in a number of brainstem 
      structures, including the solitary nucleus (NTS), lateral parabrachial nucleus 
      (LPBN), locus coeruleus (LC), and the area postrema (AP). These results indicate 
      that AVP and OXY-containing neurons in the magnocellular parts of the SON and PVN 
      alter their immediate-early gene response to AII after water intake, and that 
      this does not depend upon oro-pharyngeal factors. Furthermore, AII can induce 
      c-fos expression in a number of brainstem nuclei associated with autonomic 
      function, and these do not respond to water intake.
FAU - Xu, Z
AU  - Xu Z
AD  - Department of Anatomy, University of Cambridge, UK.
FAU - Herbert, J
AU  - Herbert J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 11128-99-7 (Angiotensin II)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 50-56-6 (Oxytocin)
SB  - IM
EIN - Brain Res 1994 Dec 26;667(2):301-2
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Arginine Vasopressin/metabolism
MH  - Blood/metabolism
MH  - Brain/cytology/*physiology
MH  - Brain Stem/metabolism
MH  - Drinking/*physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Neurons/metabolism
MH  - Osmolar Concentration
MH  - Oxytocin/metabolism
MH  - Prosencephalon/metabolism
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
EDAT- 1994/10/03 00:00
MHDA- 1994/10/03 00:01
CRDT- 1994/10/03 00:00
PHST- 1994/10/03 00:00 [pubmed]
PHST- 1994/10/03 00:01 [medline]
PHST- 1994/10/03 00:00 [entrez]
AID - 0006-8993(94)90875-3 [pii]
AID - 10.1016/0006-8993(94)90875-3 [doi]
PST - ppublish
SO  - Brain Res. 1994 Oct 3;659(1-2):157-68. doi: 10.1016/0006-8993(94)90875-3.