PMID- 7820666
OWN - NLM
STAT- MEDLINE
DCOM- 19950213
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 659
IP  - 1-2
DP  - 1994 Oct 3
TI  - TNF-alpha increases the frequency of spontaneous miniature synaptic currents in 
      cultured rat hippocampal neurons.
PG  - 226-30
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a cytokine secreted by activated 
      astrocytes and is known to alter evoked synaptic activity in slices of adult rat 
      hippocampus. In this paper we show that TNF-alpha increases the frequency of 
      spontaneous miniature synaptic currents in cultured hippocampal neurons, acting 
      at nanomolar concentrations. In addition, we show that the mRNA for the 55 kDa 
      TNF-alpha receptor (TNF-R1) is detected in embryonic rat hippocampal cultures, as 
      well as in acutely dissected embryonic and adult rat hippocampi. Possible 
      transduction pathways mediating the TNF-alpha effect are discussed.
FAU - Grassi, F
AU  - Grassi F
AD  - Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza,Italy.
FAU - Mileo, A M
AU  - Mileo AM
FAU - Monaco, L
AU  - Monaco L
FAU - Punturieri, A
AU  - Punturieri A
FAU - Santoni, A
AU  - Santoni A
FAU - Eusebi, F
AU  - Eusebi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Cytosol/metabolism
MH  - Electric Conductivity
MH  - Hippocampus/cytology/*drug effects/physiology
MH  - Neurons/*drug effects/physiology
MH  - Osmolar Concentration
MH  - Polymerase Chain Reaction
MH  - Rats/embryology
MH  - Rats, Sprague-Dawley
MH  - Receptors, Cytokine/metabolism
MH  - Synapses/*drug effects/physiology
MH  - Transcription, Genetic
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1994/10/03 00:00
MHDA- 1994/10/03 00:01
CRDT- 1994/10/03 00:00
PHST- 1994/10/03 00:00 [pubmed]
PHST- 1994/10/03 00:01 [medline]
PHST- 1994/10/03 00:00 [entrez]
AID - 0006-8993(94)90883-4 [pii]
AID - 10.1016/0006-8993(94)90883-4 [doi]
PST - ppublish
SO  - Brain Res. 1994 Oct 3;659(1-2):226-30. doi: 10.1016/0006-8993(94)90883-4.