PMID- 7821087
OWN - NLM
STAT- MEDLINE
DCOM- 19950215
LR  - 20190830
IS  - 0009-5915 (Print)
IS  - 0009-5915 (Linking)
VI  - 103
IP  - 5
DP  - 1994 Sep
TI  - Interstitial deletions of repetitive DNA blocks in dicentric human Y chromosomes.
PG  - 324-30
AB  - Cytogenetic analysis of aberrant human Y chromosomes was done by fluorescence in 
      situ hybridization (FISH) with Y specific repetitive DNA probes. It revealed an 
      interstitial deletion of different DNA blocks in two dicentric chromosome 
      structures. One deletion includes the total alphoid DNA structure of one 
      centromeric region. The second deletion includes the total repetitive DYZ5 DNA 
      structure in the pericentromeric region of one short Y arm. Both dicentric Y 
      chromosomes were iso(Yp) chromosomes with break and fusion point located in Yq11, 
      the euchromatic part of the long Y arm. Their phenotypic appearance was 
      "abnormal", resembling small monocentric Yq-chromosomes in metaphase plates. 
      Mosaic cell lines, usually included in karyotypes with dicentric Y chromosomes, 
      were not observed. It is assumed that both deletion events suppress the 
      kinetochore activity in one Y centromeric region and thus stabilize its dicentric 
      structure. Local interstitial deletion events had not been described in dicentric 
      human Y chromosomes, but are common in dicentric yeast chromosomes. This raises 
      the question of whether deletion events in dicentric human chromosomes are rare 
      or restricted to the Y chromosome or also represent a general possibility for 
      stabilization of a dicentric chromosome structure in human.
FAU - Kohler, M R
AU  - Kohler MR
AD  - Sektion Molekulare Humangenetik, Universitat Heidelberg, Germany.
FAU - Vogt, P H
AU  - Vogt PH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Chromosoma
JT  - Chromosoma
JID - 2985138R
RN  - 0 (DNA Probes)
SB  - IM
MH  - Centromere
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - DNA Probes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/genetics
MH  - Kinetochores
MH  - Male
MH  - Repetitive Sequences, Nucleic Acid/*genetics
MH  - Y Chromosome/*genetics
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1007/BF00417879 [doi]
PST - ppublish
SO  - Chromosoma. 1994 Sep;103(5):324-30. doi: 10.1007/BF00417879.