PMID- 7823087
OWN - NLM
STAT- MEDLINE
DCOM- 19950210
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 72
IP  - 4
DP  - 1994 Oct
TI  - Characteristics of somatotopic organization and spontaneous neuronal activity in 
      the region of the thalamic principal sensory nucleus in patients with spinal cord 
      transection.
PG  - 1570-87
AB  - 1. We explored the region of the principal sensory nucleus of thalamus (Vc) 
      during stereotactic surgical procedures for treatment of patients with pain after 
      spinal cord transection (n = 23). Receptive fields (RFs) of thalamic single 
      neurons and locations of sensations evoked by stimulation (projected field, PF) 
      were determined by standard methods. The cellular thalamic region where 
      sensations were evoked at < 25 microA was termed the "region of Vc." The region 
      of Vc in spinal patients was subdivided into different areas according to RF and 
      PF locations. Areas that were distant from the representation of the anesthetic 
      part of the body were termed "spinal control" areas, whereas those that were 
      adjacent to or included in the representation of the area of absolute sensory 
      loss were termed "border zone/anesthetic" areas. The region of Vc in movement 
      disorder patients were termed the "control" area. 2. Border zone/anesthetic areas 
      of thalamus often exhibited increased representations of the border of the 
      anesthetic part of the body in comparison with the representation of the same 
      parts of the body in control and spinal control areas. 3. In control and spinal 
      control areas the locations of RFs and PFs were usually well matched. However, in 
      border zone/anesthetic areas of the thalamus there was frequently a mismatch 
      between the location of RFs and PFs (RF/PF mismatch). In border zone/anesthetic 
      areas, RFs were often located on the border of the anesthetic part of the body 
      whereas PFs were referred to anesthetic parts of the body. 4. Analysis of first- 
      and higher-order properties of spontaneous neuronal activity revealed that spike 
      trains could be classified into two groups with distinct patterns of activity. 
      The R group (n = 49) was characterized by independence of sequential interspike 
      intervals (ISIs), a Poisson distribution of ISIs, initially inhibitory or flat 
      autocovariance function (acvf), and low level of high-frequency bursting. The O 
      group (n = 26) was characterized by correlation of sequential ISIs, large 
      sustained postspike facilitation on the acvf, and high prevalence of 
      high-frequency bursting--all consistent with a bursting pattern of activity. A 
      third group of spike trains (n = 17) had an initially inhibitory or flat acvf and 
      a unimodal, positively shifted, ISI distribution that did not meet criteria for a 
      Poisson distribution. 5. Spike trains in the R group were much more common in 
      control and control spinal areas, whereas those in the O group were more common 
      in border zone/anesthetic areas.(ABSTRACT TRUNCATED AT 400 WORDS)
FAU - Lenz, F A
AU  - Lenz FA
AD  - Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 
      21287-7713.
FAU - Kwan, H C
AU  - Kwan HC
FAU - Martin, R
AU  - Martin R
FAU - Tasker, R
AU  - Tasker R
FAU - Richardson, R T
AU  - Richardson RT
FAU - Dostrovsky, J O
AU  - Dostrovsky JO
LA  - eng
GR  - K08 NS-01384/NS/NINDS NIH HHS/United States
GR  - NS-28598/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Calcium Channels)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - *Brain Mapping
MH  - Calcium/physiology
MH  - Calcium Channels/physiology
MH  - Electric Stimulation
MH  - Evoked Potentials/physiology
MH  - Humans
MH  - Movement Disorders/*physiopathology
MH  - Neural Pathways/physiology
MH  - Neurons/physiology
MH  - Nociceptors/*physiopathology
MH  - Paresthesia/physiopathology
MH  - Spinal Cord Injuries/*physiopathology
MH  - Synaptic Transmission/*physiology
MH  - Thalamic Nuclei/*physiopathology
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - 10.1152/jn.1994.72.4.1570 [doi]
PST - ppublish
SO  - J Neurophysiol. 1994 Oct;72(4):1570-87. doi: 10.1152/jn.1994.72.4.1570.