PMID- 7825992
OWN - NLM
STAT- MEDLINE
DCOM- 19950216
LR  - 20191023
IS  - 0272-4936 (Print)
IS  - 0272-4936 (Linking)
VI  - 14
IP  - 3
DP  - 1994
TI  - Glucose-6-phosphate dehydrogenase, hexokinase and pyruvate kinase activities in 
      erythrocytes of neonates and adults in Basrah.
PG  - 195-200
AB  - The mean activities (95% confidence interval; number of patients) for erythrocyte 
      glucose-6-phosphate dehydrogenase (G6PD), hexokinase (HK), and pyruvate kinase 
      (PK) in haemolysate of clinically normal neonates from Basrah, Iraq were found to 
      be 3.29 (0.10; n = 456), 0.61 (0.02; n = 219), and 5.10 (0.07; n = 500), 
      respectively, all expressed as U/10(10) RBC at 37 degrees C. Comparative values 
      for apparently healthy adults were: 2.14 (0.06; n = 186), 0.41 (0.02; n = 46), 
      and 3.61 (0.07; n = 243). Differences between sexes in the mean activities of 
      each of the three enzymes were not significant (p > 0.5), being several times 
      less than the corresponding 95% confidence intervals. However, differences were 
      highly significant between neonates and adults (p < 0.001), presumably reflecting 
      the greater proportion of 'young' cells and/or their programming for higher 
      activity in cord blood. The neonate-adult difference (95% confidence interval) 
      for each enzyme was: G6PD, 1.15 (0.43); HK, 0.20 (0.14); and PK, 1.49 (0.64). 
      Some degree of G6PD-deficiency was observed in 7.9% of male and 9.7% of female 
      neonates, whereas the frequency in adults was 9.2% and 11.8% for males and 
      females, respectively. The higher frequency in females accords with expectations 
      based on gene frequency estimations.
FAU - al-Naama, M M
AU  - al-Naama MM
AD  - Department of Chemistry, College of Education, University of Basrah, Iraq.
FAU - al-Naama, L M
AU  - al-Naama LM
FAU - al-Sadoon, T A
AU  - al-Sadoon TA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Trop Paediatr
JT  - Annals of tropical paediatrics
JID - 8210625
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Confidence Intervals
MH  - Erythrocytes/chemistry/*enzymology
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Gene Frequency
MH  - Glucosephosphate Dehydrogenase/*analysis
MH  - Glucosephosphate Dehydrogenase Deficiency/*blood/*epidemiology/genetics
MH  - Hexokinase/*analysis
MH  - Humans
MH  - Infant, Newborn
MH  - Iraq/epidemiology
MH  - Male
MH  - *Population Surveillance
MH  - Pyruvate Kinase/*analysis
MH  - Reference Values
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1080/02724936.1994.11747717 [doi]
PST - ppublish
SO  - Ann Trop Paediatr. 1994;14(3):195-200. doi: 10.1080/02724936.1994.11747717.