PMID- 7826076
OWN - NLM
STAT- MEDLINE
DCOM- 19950213
LR  - 20221207
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 22
IP  - 1
DP  - 1995 Jan
TI  - [Therapeutic strategy for advanced non-small cell lung cancer].
PG  - 37-44
AB  - This paper describes the recent progress in the treatment of advanced non-small 
      cell lung cancer (NS CLC) as follows: 1) The results of single agent chemotherapy 
      in NSCLC, particularly development of new drugs, are summarized. CPT-11, taxol, 
      taxotere, vinorelbine and gemcitabine have appeared to have a response rate of 
      more than 20%. In addition results of phase I and II trials that involved these 
      agents as part of combination regimens are presented. 2) We summarize 8 
      randomized trials of combination chemotherapy compared with best supportive care. 
      These studies have provided that combination chemotherapy modestly improves 
      survival of patients with advanced NSCLC. 3) Although several randomized trials 
      with adjuvant or neoadjuvant chemotherapy have reported in the patients with 
      locally advanced NSCLC, we have still not confirmative results. 4) Cisplatin 
      based combination chemotherapy followed by chest irradiation improves outcomes of 
      the patients with stage IIIA or IIIB unresectable NSCLC as compared with 
      chemotherapy alone or radiation therapy alone. In spite of these advances further 
      investigations are necessary to improve the treatment results of patients with 
      advanced NSCLC.
FAU - Fukuoka, M
AU  - Fukuoka M
AD  - Department of Pulmonary Medicine, Osaka City General Hospital, Japan.
FAU - Yoshikawa, A
AU  - Yoshikawa A
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0W860991D6 (Deoxycytidine)
RN  - 5V9KLZ54CY (Vinblastine)
RN  - 7673326042 (Irinotecan)
RN  - P88XT4IS4D (Paclitaxel)
RN  - Q6C979R91Y (Vinorelbine)
RN  - XT3Z54Z28A (Camptothecin)
RN  - 0 (Gemcitabine)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Camptothecin/administration & dosage/analogs & derivatives
MH  - Carcinoma, Non-Small-Cell Lung/drug therapy/radiotherapy/*therapy
MH  - Clinical Trials, Phase I as Topic
MH  - Clinical Trials, Phase II as Topic
MH  - Combined Modality Therapy
MH  - Deoxycytidine/administration & dosage/analogs & derivatives
MH  - Humans
MH  - Irinotecan
MH  - Lung Neoplasms/drug therapy/radiotherapy/*therapy
MH  - Paclitaxel/administration & dosage
MH  - Vinblastine/administration & dosage/analogs & derivatives
MH  - Vinorelbine
MH  - Gemcitabine
RF  - 46
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 1995 Jan;22(1):37-44.