PMID- 7829611
OWN - NLM
STAT- MEDLINE
DCOM- 19950217
LR  - 20071114
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 80
IP  - 1
DP  - 1995 Jan
TI  - Tumor necrosis factor-alpha and interleukin-1 beta inhibit the synthesis and 
      release of renin from human decidual cells.
PG  - 195-9
AB  - Cytokines modulate hormone expression in many cell types, including the 
      expression of renin in juxtaglomerular cells. However, the effect of cytokines on 
      the expression of renin from extrarenal cells is unknown. In this paper, we have 
      examined whether tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta 
      (IL-1 beta) modulate the release of renin from human decidual cells. Continuous 
      exposure of primary decidual cell cultures from term pregnancies to TNF alpha and 
      IL-1 beta caused dose-dependent inhibition of renin release. The maximal 
      inhibitions by TNF alpha and IL-1 beta were 75.5% and 55.2%, respectively, and 
      the half-maximal effective doses of TNF alpha and IL-1 beta were 30 and 1.1 
      pmol/L, respectively. The decrease in renin release by the cytokines was 
      statistically significant on days 2-5 (P > 0.001 at each time) and was 
      accompanied by inhibition of renin synthesis and renin messenger ribonucleic acid 
      levels. The renin messenger ribonucleic acid levels in cells exposed for 4 days 
      to TNF alpha (50 ng/mL) or IL-1 beta (50 pg/mL) were 58.0% and 37.7% less than 
      those in control cells, respectively. As decidual macrophages express TNF alpha 
      and IL-1 beta, the results of this study strongly suggest a paracrine role for 
      cytokines in the regulation of decidual renin expression. The effect of these 
      cytokines on renin expression in decidual cells is opposite that in 
      juxtaglomerular cells.
FAU - Jikihara, H
AU  - Jikihara H
AD  - Division of Endocrinology, Children's Hospital Medical Center, University of 
      Cincinnati College of Medicine, Ohio 45229.
FAU - Poisner, A M
AU  - Poisner AM
FAU - Handwerger, S
AU  - Handwerger S
LA  - eng
GR  - HD-15201/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Interleukin-1)
RN  - 0 (Oligonucleotide Probes)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Base Sequence
MH  - Cells, Cultured
MH  - Decidua/cytology/*metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-1/*pharmacology
MH  - Molecular Sequence Data
MH  - Oligonucleotide Probes/genetics
MH  - RNA, Messenger/antagonists & inhibitors
MH  - Renin/*antagonists & inhibitors/genetics
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1210/jcem.80.1.7829611 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1995 Jan;80(1):195-9. doi: 10.1210/jcem.80.1.7829611.