PMID- 7830934
OWN - NLM
STAT- MEDLINE
DCOM- 19950221
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 176
IP  - 2
DP  - 1994 Aug 1
TI  - Microglial interleukin-1 alpha expression in human head injury: correlations with 
      neuronal and neuritic beta-amyloid precursor protein expression.
PG  - 133-6
AB  - Activated microglia containing IL-1 alpha-immunoreactive (IL-1 alpha +) product 
      were increased 3-fold in number in the acute phase following head injury, a risk 
      factor for later development of Alzheimer's disease, and this increase was 
      correlated with a 7-fold increase in the number of neurons with elevated 
      beta-amyloid precursor protein (beta-APP) levels (R = 0.78; P < 0.05). 
      Furthermore, clusters of beta-APP+ dystrophic neurites present in these patients 
      were invariably associated with activated IL-1 alpha + microglia. These findings 
      suggest that early overexpression of IL-1 alpha and beta-APP is a priming event 
      for later neuropathological changes evident at end stages of Alzheimer's disease.
FAU - Griffin, W S
AU  - Griffin WS
AD  - Department of Pediatrics, University of Arkansas for Medical Sciences, Little 
      Rock.
FAU - Sheng, J G
AU  - Sheng JG
FAU - Gentleman, S M
AU  - Gentleman SM
FAU - Graham, D I
AU  - Graham DI
FAU - Mrak, R E
AU  - Mrak RE
FAU - Roberts, G W
AU  - Roberts GW
LA  - eng
GR  - P01 AG012411/AG/NIA NIH HHS/United States
GR  - AG10208/AG/NIA NIH HHS/United States
GR  - NS27414/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Interleukin-1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloid beta-Protein Precursor/*biosynthesis
MH  - Craniocerebral Trauma/*metabolism
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-1/*biosynthesis
MH  - Male
MH  - Microglia/*metabolism
MH  - Middle Aged
MH  - Nerve Regeneration/physiology
MH  - Neurites/*metabolism
MH  - Neurons/*metabolism
PMC - PMC3833643
MID - NIHMS524193
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
PMCR- 2013/11/19
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
PHST- 2013/11/19 00:00 [pmc-release]
AID - 0304-3940(94)90066-3 [pii]
AID - 10.1016/0304-3940(94)90066-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1994 Aug 1;176(2):133-6. doi: 10.1016/0304-3940(94)90066-3.