PMID- 7831214
OWN - NLM
STAT- MEDLINE
DCOM- 19950223
LR  - 20161209
IS  - 0755-4982 (Print)
IS  - 0755-4982 (Linking)
VI  - 23
IP  - 26
DP  - 1994 Sep 3-10
TI  - [Human herpesvirus-6 infection and hepatitis following heart transplantation].
PG  - 1209-10
AB  - OBJECTIVES: Human Herpesvirus-6 (HHV-6) has been implicated in hepatitis and 
      HHV-6 infections have been reported in patients receiving heart transplants. We 
      investigated the occurrence of such infections and their possible relation with 
      post-transplantation hepatitis in 58 heart transplanted patients. METHODS: The 
      titre of HHV-6 antibodies was determined by anticomplement immunofluorescence 
      assay and compared with the titre of CMV antibodies determined by using ELISA. 
      RESULTS: HHV-6 seroprevalence after transplantation did not differ significantly 
      between hepatitis, control patients (without hepatitis) and the healthy general 
      population. In three controls and five hepatitis patients we observed, after 
      transplantation, a seroconversion or a significant increase of antibody titre 
      which suggested active HHV-6 infection. In six cases, HHV-6-specific IgM were 
      found whereas CMV-specific IgM were not detected. CONCLUSION: These results 
      indicate that HHV-6 infection is frequent after heart transplantation but not in 
      relation with hepatitis. The mechanism of this infection needs to be clarified 
      (either primo-infection or reactivation) and the question remains whether this 
      infection is totally asymptomatic or could induce serious illness.
FAU - Robert, C
AU  - Robert C
AD  - Laboratoire de Bacteriologie-Virologie, CNRS EP 57, CERVI, Groupe hospitalier 
      Pitie-Salpetriere, Paris.
FAU - Agut, H
AU  - Agut H
FAU - Lunel-Fabiani, F
AU  - Lunel-Fabiani F
FAU - Leger, P
AU  - Leger P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Infection a herpesvirus humain-6 et hepatite chez les transplantes cardiaques.
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Antibodies, Viral/analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Heart Transplantation/*adverse effects
MH  - Hepatitis/etiology/*microbiology
MH  - Herpesviridae Infections/etiology/immunology/*microbiology
MH  - Herpesvirus 6, Human/immunology/*isolation & purification
MH  - Humans
MH  - Retrospective Studies
EDAT- 1994/09/03 00:00
MHDA- 1994/09/03 00:01
CRDT- 1994/09/03 00:00
PHST- 1994/09/03 00:00 [pubmed]
PHST- 1994/09/03 00:01 [medline]
PHST- 1994/09/03 00:00 [entrez]
PST - ppublish
SO  - Presse Med. 1994 Sep 3-10;23(26):1209-10.