PMID- 7831303
OWN - NLM
STAT- MEDLINE
DCOM- 19950222
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 92
IP  - 2
DP  - 1995 Jan 17
TI  - Cooperative formation of high-order oligomers by retinoid X receptors: an 
      unexpected mode of DNA recognition.
PG  - 422-6
AB  - Nuclear hormone receptors are ligand-regulated transcription factors that 
      function in metazoan homeostasis and differentiation. We report here that DNA 
      recognition by at least one class of nuclear receptors, the retinoid X receptors 
      (RXRs), can occur through an unanticipated mechanism involving the cooperative 
      formation of protein tetramers and other high-order oligomers. Formation of these 
      oligomeric complexes enables RXRs alpha and gamma, but not beta, to efficiently 
      regulate transcription through response elements poorly recognized by RXR dimers. 
      Thus, oligomer formation plays an important role in determining the specificity 
      of DNA recognition by nuclear receptors and contributes to isoform-dependent 
      differences in gene regulation.
FAU - Chen, H
AU  - Chen H
AD  - Section of Microbiology, University of California at Davis 95616.
FAU - Privalsky, M L
AU  - Privalsky ML
LA  - eng
GR  - R01 CA53394/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Oligonucleotides)
RN  - 0 (RBP2 protein, human)
RN  - 0 (Rbp2 protein, rat)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinol-Binding Proteins)
RN  - 0 (Retinol-Binding Proteins, Cellular)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - DNA/*metabolism
MH  - Gene Expression Regulation
MH  - Genes, Reporter
MH  - Humans
MH  - Molecular Sequence Data
MH  - Oligonucleotides
MH  - Protein Binding
MH  - Protein Conformation
MH  - Rats
MH  - Receptors, Retinoic Acid/*metabolism
MH  - *Regulatory Sequences, Nucleic Acid
MH  - Repetitive Sequences, Nucleic Acid
MH  - Retinoid X Receptors
MH  - Retinol-Binding Proteins/metabolism
MH  - Retinol-Binding Proteins, Cellular
MH  - Structure-Activity Relationship
MH  - Transcription Factors/*metabolism
PMC - PMC42752
EDAT- 1995/01/17 00:00
MHDA- 1995/01/17 00:01
PMCR- 1995/07/17
CRDT- 1995/01/17 00:00
PHST- 1995/01/17 00:00 [pubmed]
PHST- 1995/01/17 00:01 [medline]
PHST- 1995/01/17 00:00 [entrez]
PHST- 1995/07/17 00:00 [pmc-release]
AID - 10.1073/pnas.92.2.422 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):422-6. doi: 10.1073/pnas.92.2.422.