PMID- 7831501
OWN - NLM
STAT- MEDLINE
DCOM- 19950222
LR  - 20190830
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 53
IP  - 2
DP  - 1994 Sep 22
TI  - AT1 receptor subtype mediates the inhibitory effect of central angiotensin II on 
      cerebrospinal fluid formation in the rat.
PG  - 123-9
AB  - The effect of central administration of angiotensin II (AII) on cerebrospinal 
      fluid (CSF) formation was studied in pentobarbital-anesthetized, 
      artificially-ventilated rats. CSF production was measured by the 
      ventriculocisternal perfusion method with Blue Dextran 2000 as the indicator. 
      Baseline value of CSF production was 3.35 +/- 0.08 microliters/min. 
      Intracerebroventricular (i.c.v.) infusion of AII at rates of 0.5 and 5 pg/min 
      significantly lowered (P < 0.01) CSF formation by 23% and 16%, respectively. In 
      comparison, high peptide doses (50 and 500 pg/min) did not alter this parameter. 
      The inhibitory effect of low AII doses on CSF formation was blocked by the i.c.v. 
      AT1 receptor subtype antagonists, losartan and SK&F 108566 (2.4 and 2.7 ng/min, 
      respectively), but not by the AT2 receptor subtype-specific agent, PD 123319 (3.8 
      ng/min). Peptide AII antagonists, [Sar1,Ile8]AII (5 ng/min), which binds to both 
      AT1 and AT2 receptors, had a similar effect to those of AT1-specific blockers. It 
      is concluded that AII, by controlling CSF formation, may influence the water and 
      electrolyte balance in the brain.
FAU - Chodobski, A
AU  - Chodobski A
AD  - Department of Clinical Neurosciences, Brown University/Rhode Island Hospital, 
      Providence, RI 02903.
FAU - Szmydynger-Chodobska, J
AU  - Szmydynger-Chodobska J
FAU - Vannorsdall, M D
AU  - Vannorsdall MD
FAU - Epstein, M H
AU  - Epstein MH
FAU - Johanson, C E
AU  - Johanson CE
LA  - eng
GR  - NS 27601/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Receptors, Angiotensin)
RN  - 11128-99-7 (Angiotensin II)
SB  - IM
MH  - Angiotensin II/*pharmacology
MH  - Angiotensin Receptor Antagonists
MH  - Animals
MH  - Cerebrospinal Fluid/*drug effects
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Angiotensin/*metabolism
EDAT- 1994/09/22 00:00
MHDA- 1994/09/22 00:01
CRDT- 1994/09/22 00:00
PHST- 1994/09/22 00:00 [pubmed]
PHST- 1994/09/22 00:01 [medline]
PHST- 1994/09/22 00:00 [entrez]
AID - 0167-0115(94)90613-0 [pii]
AID - 10.1016/0167-0115(94)90613-0 [doi]
PST - ppublish
SO  - Regul Pept. 1994 Sep 22;53(2):123-9. doi: 10.1016/0167-0115(94)90613-0.