PMID- 7836120
OWN - NLM
STAT- MEDLINE
DCOM- 19950228
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 77
IP  - 3
DP  - 1994 Sep
TI  - Effects of solution osmolality on absorption of select fluid replacement 
      solutions in human duodenojejunum.
PG  - 1178-84
AB  - These experiments examined relationships between initial osmolality and 
      carbohydrate (CHO) composition of an infused solution and osmolality and water 
      and CHO absorption in a test segment. A triple-lumen tube with a 10-cm mixing 
      segment and a 40-cm test segment was passed into the duodenojejunum. The infusion 
      port was approximately 10 cm beyond the pyloric sphincter. Perfusion solutions 
      were hypotonic (186 mosmol/kg; solution A), isotonic (283 mosmol/kg; solution B), 
      and hypertonic (403 mosmol/kg; solution C). All solutions contained 18 meq Na+ 
      and 3 meq K+. In the mixing segment, osmolality increased 83 mosmol/kg and 
      decreased 90 mosmol/kg for solutions A and C, respectively. Corresponding changes 
      in the test segment were an increase of 60 mosmol/kg and a decrease of 34 
      mosmol/kg. The osmolality of solution B did not change. In the test segment, mean 
      osmolality and water and total solute fluxes were not significantly different 
      among solutions, but solution C produced 27% greater fluid absorption than did 
      solution A. When net fluid movement from mixing and test segments was determined, 
      solution A produced 17% greater fluid absorption than did solution C. The mean 
      increases in plasma and urine volumes over the 80-min test period were not 
      significantly different. In the test segment, water flux correlated with CHO and 
      Na+ fluxes but not with osmolality. In conclusion, 1) significant differences in 
      solution osmolality were eliminated within the proximal duodenum and 2) perfusing 
      6% CHO solutions with osmolalities ranging from 186 to 403 mosmol/kg did not 
      produce significant differences in fluid homeostasis (plasma volume) at the end 
      of an 80-min test period.
FAU - Shi, X
AU  - Shi X
AD  - Department of Exercise Science and Internal Medicine, University of Iowa, Iowa 
      City 52242.
FAU - Summers, R W
AU  - Summers RW
FAU - Schedl, H P
AU  - Schedl HP
FAU - Chang, R T
AU  - Chang RT
FAU - Lambert, G P
AU  - Lambert GP
FAU - Gisolfi, C V
AU  - Gisolfi CV
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Carbohydrates)
RN  - 0 (Electrolytes)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Body Water/metabolism
MH  - Carbohydrates/administration & dosage/chemistry/pharmacokinetics
MH  - Duodenum/*metabolism
MH  - Electrolytes/administration & dosage/chemistry/pharmacokinetics
MH  - *Fluid Therapy
MH  - Humans
MH  - Intestinal Absorption
MH  - Intubation, Gastrointestinal
MH  - Jejunum/*metabolism
MH  - Male
MH  - Osmolar Concentration
MH  - Plasma Volume/drug effects
MH  - Potassium/pharmacokinetics
MH  - Sodium/pharmacokinetics
MH  - Urination/drug effects
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1152/jappl.1994.77.3.1178 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1994 Sep;77(3):1178-84. doi: 10.1152/jappl.1994.77.3.1178.