PMID- 7836162
OWN - NLM
STAT- MEDLINE
DCOM- 19950228
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 77
IP  - 3
DP  - 1994 Sep
TI  - Effect of carbohydrate ingestion on glucose kinetics during exercise.
PG  - 1537-41
AB  - Six well-trained men (peak pulmonary oxygen uptake = 5.03 +/- 0.11 l/min) were 
      studied during 2 h of exercise at 69 +/- 1% peak pulmonary oxygen uptake to 
      examine the effect of carbohydrate (CHO) ingestion on glucose kinetics. Subjects 
      ingested 250 ml of either a 10% glucose solution containing 6-[3H]glucose (CHO) 
      or a sweet placebo every 15 min during exercise. Glucose kinetics were assessed 
      by 6,6-[2H]glucose infusion corrected for gut-derived glucose in CHO. Plasma 
      glucose was higher (P < 0.05) in CHO from 20 min. Total glucose appearance was 
      higher in CHO due to glucose delivery from the gut (68 +/- 7 g), since hepatic 
      glucose production was reduced by 51% (29 +/- 5 vs. 59 +/- 5 g). Glucose uptake 
      was higher in CHO (96 +/- 7 vs. 60 +/- 6 g) with the ingested glucose supplying 
      67 +/- 4 g and, with the assumption that it was fully oxidized, accounted for 14 
      +/- 1% of total energy expenditure. In conclusion, CHO ingestion during prolonged 
      exercise results in suppression of hepatic glucose production and increased 
      glucose uptake. These effects appear to be mediated mainly by increased plasma 
      glucose and insulin levels.
FAU - McConell, G
AU  - McConell G
AD  - Department of Physiology, Royal Melbourne Hospital, University of Melbourne, 
      Parkville, Victoria, Australia.
FAU - Fabris, S
AU  - Fabris S
FAU - Proietto, J
AU  - Proietto J
FAU - Hargreaves, M
AU  - Hargreaves M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Dietary Carbohydrates/*pharmacology
MH  - Exercise/*physiology
MH  - Fatty Acids, Nonesterified/blood
MH  - Glucose/administration & dosage/*pharmacokinetics
MH  - Heart Rate/drug effects/physiology
MH  - Humans
MH  - Injections, Intravenous
MH  - Liver/metabolism
MH  - Male
MH  - Oxidation-Reduction
MH  - Oxygen Consumption/drug effects/physiology
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1152/jappl.1994.77.3.1537 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1994 Sep;77(3):1537-41. doi: 10.1152/jappl.1994.77.3.1537.