PMID- 7836749
OWN - NLM
STAT- MEDLINE
DCOM- 19950227
LR  - 20061115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 154
IP  - 4
DP  - 1995 Feb 15
TI  - Dramatic hyperplasia of mtv-2+ lymph node grafts in mtv-2- recipients and 
      selective stimulation of V beta 14+ T cells in recipients' lymph nodes in the DDD 
      mouse.
PG  - 1644-52
AB  - DDD/1 (DDD) mice contrast strikingly with DDD-mtv-2/mtv-2 (DDD-mtv-2) congenics 
      in their marked lymph node (LN) T cell paucity. To clarify the possible 
      difference in LN function between them, reciprocal LN grafting experiments were 
      conducted. DDD-mtv-2 LN grafts in DDD recipients underwent hyperplasia as 
      dramatic as 10-to 20-fold increase in weight between 3 and 4 wk after 
      implantation. Lymphoid cells in hyperplastic LN grafts were of recipient origin. 
      Similar hyperplasia of mtv-2-heterozygous LN grafts also occurred on various 
      hybrid backgrounds involving DDD mice. Moreover, LN grafts from BALB/c mice 
      infected with mtv-2-derived exogenous mouse mammary tumor virus (MMTV) swelled in 
      MMTV-free BALB/c recipients. Genetic analysis of DDD x (DDD x DDD-mtv-2)F1 
      backcross progeny demonstrated that LN hyperplasia was closely linked to mtv-2. 
      The frequencies of V beta 5+ and V beta 8+ T cells unresponsive to mtv-2-encoded 
      superantigen (SAg) changed with practically the same kinetics in both LN grafts 
      and recipients' LN. Thus, the cells responsible for LN hyperplasia were 
      polyclonal. V beta 14+ CD4+ cells responsive to mtv-2 SAg were specifically 
      stimulated in recipients' LN but selectively deleted in hyperplastic LN grafts. 
      DDD mice carrying hyperplastic mtv-2+ LN grafts or pretreated with mtv-2+ spleen 
      cells developed an unresponsive state in terms of influx of mtv-2- lymphoid cells 
      into mtv-2+ LN grafts. These results indicate that mtv-2 gene products including 
      SAg may stimulate mtv-2- lymphoid cells of recipients and cause them to migrate 
      into mtv-2+ LN grafts in a nonspecific manner with resulting LN hyperplasia.
FAU - Matsuzawa, A
AU  - Matsuzawa A
AD  - Laboratory Animal Research Center, University of Tokyo, Japan.
FAU - Nakano, H
AU  - Nakano H
FAU - Sakamoto, S
AU  - Sakamoto S
FAU - Yoshimoto, T
AU  - Yoshimoto T
FAU - Nariuchi, H
AU  - Nariuchi H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, Viral)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Superantigens)
SB  - IM
GS  - mtv-2
MH  - Animals
MH  - Antigens, Viral/genetics/*physiology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Crosses, Genetic
MH  - Female
MH  - Graft Survival
MH  - Hyperplasia
MH  - Lymph Nodes/immunology/pathology/*transplantation
MH  - Male
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Models, Immunological
MH  - Organ Size
MH  - Receptors, Antigen, T-Cell, alpha-beta/biosynthesis/*genetics
MH  - Spleen/cytology
MH  - Superantigens/genetics/*physiology
MH  - T-Lymphocytes/pathology/transplantation
EDAT- 1995/02/15 00:00
MHDA- 1995/02/15 00:01
CRDT- 1995/02/15 00:00
PHST- 1995/02/15 00:00 [pubmed]
PHST- 1995/02/15 00:01 [medline]
PHST- 1995/02/15 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1995 Feb 15;154(4):1644-52.