PMID- 7843202
OWN - NLM
STAT- MEDLINE
DCOM- 19950306
LR  - 20190813
IS  - 0340-6199 (Print)
IS  - 0340-6199 (Linking)
VI  - 153
IP  - 11
DP  - 1994 Nov
TI  - Pharmacokinetics of recombinant human erythropoietin in children treated with 
      continuous ambulatory peritoneal dialysis.
PG  - 850-4
AB  - In children treated by continuous ambulatory peritoneal dialysis (CAPD) renal 
      anaemia is preferably treated by intraperitoneal administration of 
      erythropoietin, since subcutaneous administration is painful and frightening for 
      the child. Pharmacokinetics of erythropoietin were studied in three groups of 
      children treated by CAPD. In group subcutaneous (SC) (n = 5) erythropoietin was 
      administered subcutaneously, whereas in group intraperitoneal 1 (IP1) (n = 8) and 
      intraperitoneal 2 (IP2) (n = 8) erythropoietin was given intraperitoneally during 
      a 12-h dwell. Group IP1 received erythropoietin in 20 ml/kg of dialysis fluid, 
      while in group IP2 the hormone was added to only 50 ml of dialysate, irrespective 
      of body weight. The median area under the curve (AUC) was 4064 mU.h/ml (range 
      2647-24357) in group SC, 1698 (570-5514) in group IP1 and 3577 (1225-6555) in 
      group IP2. In comparison to group SC the AUC was significantly lower in group IP1 
      (Wilcoxon: P = 0.02). The difference between group SC and group IP2 was not 
      statistically significant. CONCLUSION: In children on CAPD the resorption of 
      erythropoietin after intraperitoneal administration, measured as AUC, is similar 
      to subcutaneous administration, when erythropoietin is administered in 50 ml of 
      dialysate. The dose needed to treat renal anaemia with erythropoietin 
      administered intraperitoneally this way will have to be established in a 
      therapeutic study.
FAU - Reddingius, R E
AU  - Reddingius RE
AD  - Department of Paediatrics, Sint Radboud University Hospital, Nijmegen, The 
      Netherlands.
FAU - Schroder, C H
AU  - Schroder CH
FAU - Koster, A M
AU  - Koster AM
FAU - Monnens, L A
AU  - Monnens LA
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 0 (Recombinant Proteins)
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Adolescent
MH  - Anemia/drug therapy
MH  - Child
MH  - Child, Preschool
MH  - Erythropoietin/administration & dosage/blood/*pharmacokinetics/therapeutic use
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infusions, Parenteral
MH  - Injections, Subcutaneous
MH  - Kidney Failure, Chronic/metabolism/therapy
MH  - Male
MH  - *Peritoneal Dialysis, Continuous Ambulatory
MH  - Recombinant Proteins/pharmacokinetics
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1007/BF01972896 [doi]
PST - ppublish
SO  - Eur J Pediatr. 1994 Nov;153(11):850-4. doi: 10.1007/BF01972896.