PMID- 7844007
OWN - NLM
STAT- MEDLINE
DCOM- 19950309
LR  - 20131121
IS  - 0017-6192 (Print)
IS  - 0017-6192 (Linking)
VI  - 42
IP  - 12
DP  - 1994 Dec
TI  - [Maturation of postsynaptic acetylcholine receptors in cochlear outer hair 
      cells].
PG  - 738-43
AB  - Sound transduction in the inner ear is controlled by olivocochlear efferents 
      terminating predominantly at outer hair cells (OHC). Development of efferent 
      fibers and thereby of postsynaptic OHC receptors was studied 
      immunohistochemically in 13 cochleae from fetal guinea pigs. The gestational ages 
      of the animals ranged from gestational day (GD) 35 to GD 56. To visualize 
      nicotinic acetylcholine receptors (nAChR), sera were used from myasthenia gravis 
      patients with confirmed nAChR antibodies. At GD 53 no staining was observed, 
      whereas at GD 58 a striking nAChR-immunoreactivity was found. In cochleae from 
      adult animals postsynaptic receptors were visualized at the bases of all three 
      rows of OHCs. The region of the inner hair cells (IHC) was not stained. The 
      present results indicate that nAChRs in guinea pig cochleae develop between GD 53 
      and GD 58. Maturation of the postsynaptic nAChRs coincides with development of 
      OHC motile properties.
FAU - Plinkert, P K
AU  - Plinkert PK
AD  - Universitats-HNO-Klinik Tubingen.
FAU - Ptok, M
AU  - Ptok M
FAU - Zenner, H P
AU  - Zenner HP
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Die Reifung postsynaptischer Acetylcholinrezeptoren an cochlearen ausseren 
      Haarzellen.
PL  - Germany
TA  - HNO
JT  - HNO
JID - 2985099R
RN  - 0 (Immune Sera)
RN  - 0 (Receptors, Cholinergic)
RN  - 0 (Receptors, Nicotinic)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/*physiology
MH  - Animals
MH  - Efferent Pathways/embryology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Gestational Age
MH  - Guinea Pigs
MH  - Hair Cells, Auditory, Inner/embryology
MH  - Hair Cells, Auditory, Outer/*embryology
MH  - Hearing/physiology
MH  - Humans
MH  - Immune Sera
MH  - Organ of Corti/embryology
MH  - Pregnancy
MH  - Receptors, Cholinergic/*physiology
MH  - Receptors, Nicotinic/*physiology
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
PST - ppublish
SO  - HNO. 1994 Dec;42(12):738-43.