PMID- 7844524 OWN - NLM STAT- MEDLINE DCOM- 19950306 LR - 20071011 IS - 0022-1317 (Print) IS - 0022-1317 (Linking) VI - 76 ( Pt 1) DP - 1995 Jan TI - Human herpesvirus 6 (strain U1102) encodes homologues of the conserved herpesvirus glycoprotein gM and the alphaherpesvirus origin-binding protein. PG - 147-52 AB - The nucleotide sequence of 3,134 bp from the genome of human herpesvirus 6 (HHV-6) strain U1102 was determined. The sequence overlaps and is contiguous with the 21,858 bp nucleotide sequence published by us previously. The sequence reported here encodes two open reading frames, named 18L and 19R. The protein encoded by 18L shares amino acid sequence similarity with the multiply hydrophobic glycoprotein M conserved in the genomes of all herpesviruses sequenced to date. ORF 19R encodes a protein which shares a significant degree of amino acid sequence conservation with the origin-binding protein homologues encoded by members of the alphaherpesvirus subgroup, but does not share detectable amino acid sequence homology with positionally analogous open reading frames present in the genomes of other betaherpesviruses or in the genomes of gammaherpesviruses. FAU - Lawrence, G L AU - Lawrence GL AD - MRC Laboratory of Molecular Biology, Cambridge, UK. FAU - Nicholas, J AU - Nicholas J FAU - Barrell, B G AU - Barrell BG LA - eng SI - GENBANK/M68963 PT - Journal Article PL - England TA - J Gen Virol JT - The Journal of general virology JID - 0077340 RN - 0 (DNA-Binding Proteins) RN - 0 (Viral Envelope Proteins) RN - 0 (Viral Proteins) RN - 0 (origin-binding proteins, viral) SB - IM MH - Amino Acid Sequence MH - Conserved Sequence MH - Cytomegalovirus/genetics MH - DNA-Binding Proteins/*genetics MH - Herpesviridae/*genetics MH - Herpesvirus 6, Human/*genetics MH - Molecular Sequence Data MH - Open Reading Frames MH - Sequence Alignment MH - Viral Envelope Proteins/chemistry/*genetics MH - Viral Proteins/*genetics EDAT- 1995/01/01 00:00 MHDA- 1995/01/01 00:01 CRDT- 1995/01/01 00:00 PHST- 1995/01/01 00:00 [pubmed] PHST- 1995/01/01 00:01 [medline] PHST- 1995/01/01 00:00 [entrez] AID - 10.1099/0022-1317-76-1-147 [doi] PST - ppublish SO - J Gen Virol. 1995 Jan;76 ( Pt 1):147-52. doi: 10.1099/0022-1317-76-1-147.