PMID- 7855195
OWN - NLM
STAT- MEDLINE
DCOM- 19950316
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 113
IP  - 2
DP  - 1993
TI  - Behavioral characterization of alpha-ethyltryptamine, a tryptamine derivative 
      with MDMA-like properties in rats.
PG  - 284-7
AB  - Several reports have speculated that the tryptamine-derived drug 
      alpha-ethyltryptamine (AET) may have effects similar to those of the 
      amphetamine-derived drug 3,4-methylenedioxymethamphetamine (MDMA). Indeed, the US 
      Drug Enforcement Administration has recently placed AET on the Schedule I list 
      because of its putative similarity to MDMA. The Behavioral Pattern Monitor, which 
      quantifies locomotor and investigatory responses of rats, was used to 
      characterize the effects of AET in a paradigm that distinguishes between the 
      effects of traditional hallucinogens, amphetamine-like stimulants, and MDMA-like 
      drugs. First, a dose-response study revealed that all doses of AET tested (5, 10, 
      20 mg/kg) significantly increased locomotor activity. Locomotor hyperactivity is 
      produced by MDMA or amphetamine-like stimulants, but not by classical 
      hallucinogens, such as LSD or mescaline. Additionally, AET significantly 
      decreased measures of investigatory behavior. Similar decreases occur with MDMA 
      or hallucinogen administration. Second, as with MDMA, the locomotor hyperactivity 
      induced by AET was attenuated by pretreatment (10 mg/kg) with the serotonin 
      reuptake inhibitor fluoxetine. Thus, AET, a tryptamine-derived drug, appears to 
      produce an MDMA-like profile of behavioral changes by virtue of releasing 
      presynaptic serotonin.
FAU - Krebs, K M
AU  - Krebs KM
AD  - Department of Psychology, University of California at San Diego, La Jolla 92093.
FAU - Geyer, M A
AU  - Geyer MA
LA  - eng
GR  - DA02925/DA/NIDA NIH HHS/United States
GR  - MH00188/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Receptors, Presynaptic)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Tryptamines)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 333DO1RDJY (Serotonin)
RN  - GR181O3R32 (etryptamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Exploratory Behavior/drug effects
MH  - Fluoxetine/pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/antagonists & 
      inhibitors/pharmacokinetics/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Presynaptic/drug effects/metabolism
MH  - Receptors, Serotonin/drug effects/metabolism
MH  - Serotonin/metabolism
MH  - Tryptamines/antagonists & inhibitors/pharmacokinetics/*pharmacology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1007/BF02245712 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1993;113(2):284-7. doi: 10.1007/BF02245712.