PMID- 7855735
OWN - NLM
STAT- MEDLINE
DCOM- 19950314
LR  - 20151119
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 18
IP  - 3
DP  - 1994 Nov
TI  - Binding of 125I-iodovinyltetrabenazine to CNS vesicular monoamine transport 
      sites.
PG  - 225-32
AB  - Binding characteristics of a novel radioiodinated tetrabenazine (TBZ) analog 
      (iodovinyltetrabenazine; 125I-TBZ-Fraction I) were evaluated. In rat striatal 
      homogenates, 125I-TBZ-I displayed a pharmacological profile consistent with 
      specific binding to vesicular monoamine transport (VMAT) sites. In vitro 
      autoradiographic studies using rat brain sections further demonstrated that 
      125I-TBZ-I labeled the regions rich in VMAT sites, and it may be a useful marker 
      for these sites. This novel radioiodinated ligand, with high specific activity 
      and high binding affinity, may provide a powerful tool for the in vitro 
      assessment of neuronal loss in various neurodegenerative diseases.
FAU - Kung, M P
AU  - Kung MP
AD  - Department of Radiology, University of Pennsylvania, Philadelphia 19104.
FAU - Canney, D J
AU  - Canney DJ
FAU - Frederick, D
AU  - Frederick D
FAU - Zhuang, Z
AU  - Zhuang Z
FAU - Billings, J J
AU  - Billings JJ
FAU - Kung, H F
AU  - Kung HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Biomarkers)
RN  - 0 (Iodine Radioisotopes)
RN  - Z9O08YRN8O (Tetrabenazine)
SB  - IM
MH  - Animals
MH  - Biogenic Monoamines/*metabolism
MH  - Biological Transport
MH  - Biomarkers
MH  - Brain/*metabolism
MH  - Iodine Radioisotopes
MH  - Male
MH  - Neostriatum/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tetrabenazine/analogs & derivatives/*pharmacokinetics
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1002/syn.890180308 [doi]
PST - ppublish
SO  - Synapse. 1994 Nov;18(3):225-32. doi: 10.1002/syn.890180308.