PMID- 7858737
OWN - NLM
STAT- MEDLINE
DCOM- 19950321
LR  - 20190904
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 132
IP  - 2
DP  - 1995 Feb
TI  - Sulfoconjugated and free plasma catecholamine levels at rest and during exercise 
      in patients with idiopathic dilated cardiomyopathy.
PG  - 181-91
AB  - Plasma levels of sulfoconjugated (sc) catecholamines (CA) have been shown to be 
      increased with activation of the sympathoadrenal system in a number of clinical 
      settings. We evaluated the relation between scCA and clinical or hemodynamic 
      parameters of patients with idiopathic dilated cardiomyopathy (IDC) at rest and 
      during incremental exercise testing. Eleven healthy subjects, nine patients in 
      New York Heart Association (NYHA) functional class I (IDC-A group) and 11 in NYHA 
      functional class II and III (IDC-B group) performed a symptom-limited, graded 
      bicycle exercise test. Resting, peak and various postexercise levels of plasma 
      free and scCA were determined by high-pressure liquid chromatography. Resting CA 
      levels obtained in the supine position were remarkable for elevations of free 
      norepinephrine (NE) in IDC-B patients (355 +/- 157 ng/l) as compared to IDC-A 
      patients (177 +/- 54, p = 0.006) or healthy controls (193 +/- 74, p = 0.007). 
      Similarly, scNE was highest in IDC-B patients with 1856 +/- 1089 ng/l, followed 
      by IDC-A (1028 +/- 187, p = 0.025) and control subjects (1109 +/- 440, p = 
      0.025). There was a highly significant correlation between free and scNE (r = 
      0.76, p < 0.0005). Whereas resting free dopamine (DA) levels were comparable in 
      all three groups, scDA was found to be elevated clearly in IDC-B patients (8772 
      +/- 2097 ng/l) and significantly different to IDC-A (5786 +/- 2481, p = 0.01) or 
      control subjects (4892 +/- 1575, p = 0.0005). The NYHA functional class and 
      maximum exercise performance correlated best with resting scDA (r = 0.68, p = 
      0.001 and r = 0.56, p = 0.005, respectively). At peak exercise, IDC-B patients 
      exhibited a significant decrease in scNE and sc epinephrine (E) (from 1856 +/- 
      1089 to 1495 +/- 932 ng/l, p < 0.005 and from 491 +/- 173 to 282 +/- 143 ng/l, p 
      < 0.01) compared to controls (from 1109 +/- 444 to 1094 +/- 548 ng/l and from 379 
      +/- 200 to 329 +/- 134 ng/l). In IDC-B patients this decrease in scNE and scE at 
      peak exercise was related inversely to the rise in free NE and E (r = -0.81, p < 
      0.005 and r = -0.68, p < 0.05). Resting hemodynamic indices generally were 
      reflected better by some free CA rather than by conjugated forms or by parameters 
      of clinical performance. These findings suggest that in addition to free or scNE 
      levels, resting scDA is elevated in symptomatic patients with IDC.(ABSTRACT 
      TRUNCATED AT 400 WORDS)
FAU - Dobnig, H
AU  - Dobnig H
AD  - Department of Internal Medicine (Division of Endocrinology and Cardiology), 
      Karl-Franzens-University, Graz, Austria.
FAU - Leb, G
AU  - Leb G
FAU - Lipp, R
AU  - Lipp R
FAU - Porta, S
AU  - Porta S
FAU - Dusleag, J
AU  - Dusleag J
FAU - Eber, B
AU  - Eber B
FAU - Klein, W
AU  - Klein W
FAU - Krejs, G J
AU  - Krejs GJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Catecholamines)
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/*metabolism
MH  - Catecholamines/*blood
MH  - Exercise Test
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rest
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 10.1530/eje.0.1320181 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 1995 Feb;132(2):181-91. doi: 10.1530/eje.0.1320181.