PMID- 7861710
OWN - NLM
STAT- MEDLINE
DCOM- 19950321
LR  - 20190725
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 46
IP  - 4
DP  - 1994 Oct
TI  - Cholesteryl ester transfer in patients with renal failure or renal transplants.
PG  - 1147-53
AB  - Plasma newly-synthesized cholesteryl ester transfer (NCET) rate and 
      concentrations of lipids, lipoproteins and apolipoproteins A1 and B were measured 
      in chronic renal failure patients (dialysis independent and dialysis dependent), 
      patients with a functioning renal transplant and in healthy control subjects with 
      comparable ages and plasma triglycerides. Plasma NCET rates and apoB 
      concentrations were significantly higher in patients treated by continuous 
      ambulatory peritoneal dialysis (CAPD) compared with controls. In normolipidemic 
      subjects (cholesterol < 6.5 mmol/liter, triglycerides < 2.0 mmol/liter), plasma 
      NCET rates did not differ significantly from rates in the corresponding control 
      subjects. In hyperlipidemic subjects, plasma NCET rates were significantly higher 
      than rates in the normolipidemic subgroup. Plasma NCET rates were correlated 
      closely with plasma apoB levels in all renal patients combined (r = 0.754, N = 
      53, P < 0.001) and with plasma cholesteryl ester mass transfer (r = 0.853, N = 
      13, P < 0.001). We conclude that, in the absence of hyperlipidemia, plasma NCET 
      rate is normal in patients with chronic renal failure irrespective of the 
      treatment for uremia, and when hyperlipidemia is present NCET rates are raised 
      and may contribute to elevated levels of the proatherogenic apoB-containing 
      lipoproteins.
FAU - Corboy, J
AU  - Corboy J
AD  - Department of Medicine, University of Otago, Dunedin, New Zealand.
FAU - Sutherland, W H
AU  - Sutherland WH
FAU - Walker, R J
AU  - Walker RJ
FAU - Robertson, M C
AU  - Robertson MC
FAU - Cox, C M
AU  - Cox CM
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Apolipoproteins B)
RN  - 0 (Cholesterol Esters)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Apolipoproteins B/blood
MH  - Biological Transport, Active
MH  - Cholesterol Esters/*blood
MH  - Female
MH  - Humans
MH  - Hyperlipidemias/blood/complications
MH  - Kidney Failure, Chronic/*blood/complications/therapy
MH  - Kidney Transplantation/adverse effects/*physiology
MH  - Male
MH  - Middle Aged
MH  - Renal Dialysis
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - S0085-2538(15)58659-6 [pii]
AID - 10.1038/ki.1994.378 [doi]
PST - ppublish
SO  - Kidney Int. 1994 Oct;46(4):1147-53. doi: 10.1038/ki.1994.378.