PMID- 7863237
OWN - NLM
STAT- MEDLINE
DCOM- 19950323
LR  - 20080213
IS  - 0085-5928 (Print)
IS  - 0085-5928 (Linking)
VI  - 205
DP  - 1994
TI  - Epithelial cytotoxicity, immune responses, and inflammatory components of 
      Helicobacter pylori gastritis.
PG  - 11-21
AB  - To clarify the mechanisms of the gastric mucosal immune--inflammatory response to 
      Helicobacter pylori infection, surgical and biopsy specimens from asymptomatic 
      uninfected, gastritis-free individuals and from H. pylori-positive ulcer patients 
      with chronic gastritis were investigated using light and electron microscopy. 
      Activation of the antigen-transporting endocytic--endosomal system, enhanced 
      expression of the antigen-processing enzyme cathepsin E and de novo expression of 
      antigen-presenting human leukocyte antigen (HLA)-DR molecules have been detected 
      in H. pylori-colonized gastric epithelium. These findings may be crucial in the 
      production of a mucosal immune-inflammatory response to H. pylori infection. 
      Cytoplasmic swelling and vacuolation, micropapillary change, mucin loss, erosion 
      of the juxtaluminal cytoplasm and cell desquamation were the main effects of 
      bacterial cytotoxicity on gastric surface-foveolar epithelium. Activated 
      macrophages and granulocytes (partly linked to the mucosal IgG immune response) 
      concentrate in the foveolar-neck region of the mucosa, where they may enhance 
      damage and impair regeneration of the epithelium. Both direct bacterial 
      cytotoxicity and inflammatory cell aggression against gastric epithelium may 
      predispose the patient to peptic ulcer disease.
FAU - Fiocca, R
AU  - Fiocca R
AD  - Dept. of Pathology and Genetics, University of Pavia, Italy.
FAU - Luinetti, O
AU  - Luinetti O
FAU - Villani, L
AU  - Villani L
FAU - Chiaravalli, A M
AU  - Chiaravalli AM
FAU - Capella, C
AU  - Capella C
FAU - Solcia, E
AU  - Solcia E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Gastroenterol Suppl
JT  - Scandinavian journal of gastroenterology. Supplement
JID - 0437034
SB  - IM
MH  - Eosinophils
MH  - Gastric Mucosa/immunology/microbiology/pathology/*ultrastructure
MH  - Gastritis/immunology/microbiology/*pathology
MH  - Helicobacter Infections/immunology/*pathology
MH  - *Helicobacter pylori/pathogenicity
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunohistochemistry
MH  - Inflammation/pathology
MH  - Macrophages
MH  - Microscopy, Electron
MH  - Neutrophils
MH  - Stomach Ulcer/immunology/microbiology/*pathology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Scand J Gastroenterol Suppl. 1994;205:11-21.