PMID- 7864086
OWN - NLM
STAT- MEDLINE
DCOM- 19950321
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 268
IP  - 2 Pt 1
DP  - 1995 Feb
TI  - Changes in contractile protein mRNA accumulation in response to spaceflight.
PG  - C466-71
AB  - Ten rats were exposed to 9 days of zero gravity aboard the National Aeronautics 
      and Space Administration SLS-1 space mission (June 1991). Levels of fast and slow 
      isoform mRNAs from six contractile protein gene families were quantified in the 
      flight soleus and extensor digitorum longus (EDL) muscles. The gene families 
      studied were myosin light chain-1 (MLC-1), myosin light chain-2 (MLC-2), troponin 
      (Tn) T, TnI, TnC, and tropomyosin. In the EDL muscle there was no change in slow 
      mRNA levels with a general increase in fast mRNA levels from 23 to 232%. Changes 
      in slow mRNA levels were seen in the flight soleus muscle with TnCslow and 
      TnTslow levels increasing slightly, and MLC-1slow a, MLC-1slow b, TnIslow, 
      alpha-Tmslow, and MLC-2slow levels decreasing. All fast mRNA levels increased in 
      the flight soleus muscle from 170 to 1,100%. We can conclude that exposure to 
      zero gravity results in 1) a general increase in fast mRNA levels in both fast 
      and slow muscles and 2) differing directional changes in slow mRNA accumulation 
      in the soleus muscle.
FAU - Esser, K A
AU  - Esser KA
AD  - Muscle Development Unit, Children's Medical Research Institute, Wentworthville, 
      New South Wales, Australia.
FAU - Hardeman, E C
AU  - Hardeman EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Contractile Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Contractile Proteins/chemistry/*genetics
MH  - Hindlimb
MH  - Isomerism
MH  - Muscles/metabolism
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Space Flight
MH  - Time Factors
MH  - Toes
MH  - *Weightlessness
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 10.1152/ajpcell.1995.268.2.C466 [doi]
PST - ppublish
SO  - Am J Physiol. 1995 Feb;268(2 Pt 1):C466-71. doi: 10.1152/ajpcell.1995.268.2.C466.