PMID- 7864135
OWN - NLM
STAT- MEDLINE
DCOM- 19950321
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 268
IP  - 2 Pt 1
DP  - 1995 Feb
TI  - Induction of liver growth in normal mice by infusion of hepatocyte growth 
      factor/scatter factor.
PG  - G380-6
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a potent stimulator of DNA 
      synthesis in a variety of epithelial cells, including hepatocytes, and has been 
      implicated in liver regeneration. We show here that combining dextran sulfate 
      with HGF/SF markedly increases the plasma concentrations of HGF/SF that are 
      achieved during intraperitoneal infusion. Three days of administration of HGF/SF 
      by this mechanism caused a dose-dependent increase in liver wet weight. Mitotic 
      figures were rarely observed in control livers but were abundant in livers 
      exposed to HGF/SF, and liver DNA content was elevated. Serum levels of 
      triglycerides, cholesterol, total protein, and albumin were also dose dependently 
      increased, whereas alkaline phosphatase was reduced. From these data we conclude 
      1) that combining HGF/SF with dextran sulfate provides a novel method for 
      delivering HGF/SF in a continuous manner, 2) that HGF/SF can induce liver growth 
      in an intact animal, and 3) that HGF/SF-induced liver enlargement is associated 
      with changes in serum biochemistry.
FAU - Roos, F
AU  - Roos F
AD  - Department of Endocrine Research, Genentech, Incorporated, South San Francisco, 
      California 94080.
FAU - Ryan, A M
AU  - Ryan AM
FAU - Chamow, S M
AU  - Chamow SM
FAU - Bennett, G L
AU  - Bennett GL
FAU - Schwall, R H
AU  - Schwall RH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Drug Combinations)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Animals
MH  - Dextran Sulfate/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Combinations
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Infusion Pumps
MH  - Injections, Intraperitoneal
MH  - Liver/cytology/*drug effects/*growth & development
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 10.1152/ajpgi.1995.268.2.G380 [doi]
PST - ppublish
SO  - Am J Physiol. 1995 Feb;268(2 Pt 1):G380-6. doi: 10.1152/ajpgi.1995.268.2.G380.