PMID- 7865476
OWN - NLM
STAT- MEDLINE
DCOM- 19950330
LR  - 20191023
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 8
IP  - 3
DP  - 1994 Dec
TI  - Influence of alpha-melanocyte stimulating hormone on induction of contact 
      hypersensitivity and tolerance.
PG  - 187-93
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been demonstrated to be the primary 
      molecular mediator of impaired contact hypersensitivity induction after 
      ultraviolet B radiation, but the mediator of ultraviolet B-induced tolerance 
      remains obscure. Since alpha-melanocyte stimulating hormone (alpha-MSH) is 
      generated within ultraviolet B-exposed skin, experiments were conducted to 
      determine whether the cutaneous immune deficit caused by alpha-MSH is mediated by 
      a TNF-alpha-dependent pathway, and/or whether alpha-MSH is responsible for 
      UVB-induced tolerance. When dinitrofluorobenzene was painted on alpha-MSH-treated 
      skin of ultraviolet B-susceptible and ultraviolet B-resistant strains of mice, 
      only weak contact hypersensitivity was induced. However, neutralizing 
      anti-TNF-alpha antibodies failed to restore contact hypersensitivity 
      responsiveness to mice treated with alpha-MSH. Moreover, mice that first 
      encountered hapten via alpha-MSH-treated skin failed to acquire tolerance; 
      instead, these mice retained the ability to develop and display intense contact 
      hypersensitivity when hapten was painted subsequently on normal (untreated) skin. 
      We conclude that alpha-MSH can interfere with contact hypersensitivity induction, 
      but cannot be considered a mediator of ultraviolet B-induced tolerance because 
      skin treated with this neuropeptide does not support tolerance induction when 
      hapten is applied epicutaneously.
FAU - Shimizu, T
AU  - Shimizu T
AD  - Department of Dermatology, Hokkaido University School of Medicine, Sapporo, 
      Japan.
FAU - Streilein, J W
AU  - Streilein JW
LA  - eng
GR  - AI-22072/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Antibodies)
RN  - 0 (Haptens)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 581-05-5 (alpha-MSH)
RN  - D241E059U6 (Dinitrofluorobenzene)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology/pharmacology
MH  - Dermatitis, Contact/*etiology/*physiopathology
MH  - Dinitrofluorobenzene/pharmacology
MH  - Haptens/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Radiation Tolerance/*physiology
MH  - Skin/drug effects/radiation effects
MH  - Tumor Necrosis Factor-alpha/immunology/pharmacology/physiology
MH  - Ultraviolet Rays
MH  - alpha-MSH/metabolism/pharmacology/*physiology
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 0923-1811(94)90053-1 [pii]
AID - 10.1016/0923-1811(94)90053-1 [doi]
PST - ppublish
SO  - J Dermatol Sci. 1994 Dec;8(3):187-93. doi: 10.1016/0923-1811(94)90053-1.