PMID- 7866054
OWN - NLM
STAT- MEDLINE
DCOM- 19950327
LR  - 20171116
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 93
IP  - 7
DP  - 1994 Jul
TI  - Increased production of tumor necrosis factor-alpha and release of soluble CD4 
      and CD8 molecules, but decreased responsiveness to phytohemagglutinin in patients 
      with nasopharyngeal carcinoma.
PG  - 569-75
AB  - Twelve patients with nasopharyngeal carcinoma (NPC) were studied for spontaneous 
      and phytohemagglutin (PHA)-stimulated production of cytokines, soluble markers 
      and [3H] thymidine incorporation by mononuclear cells. The same number of 
      patients with skin cancer and healthy subjects were used as control groups. Our 
      results showed that the NPC group produced much more tumor necrosis factor-alpha 
      (TNF alpha), soluble CD4 (sCD4) and CD8 (sCD8) in PHA-stimulated mononuclear cell 
      supernatants than those in the other two groups. The levels of soluble 
      interleukin-2 receptor (sIL-2R) and gamma-interferon (IFN gamma) in 
      PHA-stimulated supernatants were at the same high level in the NPC and healthy 
      subjects groups while the concentrations were much lower in the skin cancer 
      group. We also noticed that the early stage group in NPC patients had higher 
      levels of interleukin-1 alpha (IL-1 alpha), TNF alpha, IFN gamma and sIL-2R in 
      both spontaneous and PHA-stimulated mononuclear cell supernatants. The 
      stimulation index of PHA-responsiveness was 155, 5.2 and 37, respectively, in the 
      healthy subjects, skin cancer and NPC groups. The PHA-responsiveness was 
      depressed in both the NPC and skin cancer groups. It seems that cancer patients 
      have an impaired T cell mitogenic response after mitogen stimulation. NPC 
      patients had better immune response than skin cancer patients in immune factor 
      release or PHA-responsiveness.
FAU - Kuo, W R
AU  - Kuo WR
AD  - Department of Otolaryngology, Kaohsiung Medical College Hospital, Taiwan R.O.C.
FAU - Yu, H S
AU  - Yu HS
FAU - Chang, K L
AU  - Chang KL
FAU - Juan, K H
AU  - Juan KH
FAU - Jan, Y S
AU  - Jan YS
FAU - Yu, C L
AU  - Yu CL
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Phytohemagglutinins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - CD4 Antigens/*metabolism
MH  - CD8 Antigens/*metabolism
MH  - Humans
MH  - Leukocytes, Mononuclear/metabolism
MH  - Lymphocyte Activation
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*immunology
MH  - Phytohemagglutinins/*pharmacology
MH  - Solubility
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
PST - ppublish
SO  - J Formos Med Assoc. 1994 Jul;93(7):569-75.