PMID- 7869858
OWN - NLM
STAT- MEDLINE
DCOM- 19950330
LR  - 20190814
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 29
IP  - 11
DP  - 1994 Nov
TI  - n-3 fatty acids inhibit defects and fatty acid changes caused by phenytoin in 
      early gestation in mice.
PG  - 771-8
AB  - Our previous work has shown that n-3 fatty acids exert a protective effect 
      against phenytoin-induced cleft palate when phenytoin was administered 
      midgestation [gestational days (GD) 12 and 13] to CD-1 mice. The effects of 
      dietary n-3 fatty acids on phenytoin teratogenicity were investigated at an 
      earlier gestational period (GD 9) to examine whether n-3 fatty acids could exert 
      protective action against other teratogenic effects of phenytoin apart from cleft 
      palate. The effect of phenytoin exposure on maternal hepatic polyunsaturated 
      fatty acid composition was also studied since delta 6 desaturase activity has 
      been shown to be modified by pharmacological action. Female CD-1 mice were fed a 
      standard laboratory diet (SLD), safflower oil (SAFF) or a cod liver/linseed oil 
      (CLO/LO)-based diet for three weeks prior to impregnation and throughout 
      pregnancy. Pregnant mice were administered a single i.p. dose of phenytoin on GD 
      9, and teratological assessments were performed on GD 19. Tissues were harvested 
      on GD 10 for maternal hepatic phospholipid fatty acid analysis from another group 
      of phenytoin-treated mice. The CLO/LO and the SLD mice, as compared to the 
      SAFF-fed animals, showed a reduction in total malformations and fetal growth 
      retardation due to phenytoin. Open eye defect was the only anomaly induced by 
      phenytoin in the CLO/LO fetuses while phenytoin produced a variety of 
      malformations in the SAFF fetuses such as tail defects, cleft palate, open eye 
      and absence or blockage of the ureter.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - High, K A
AU  - High KA
AD  - School of Dietetics and Human Nutrition, McGill University, Ste. Anne de 
      Bellevue, Quebec, Canada.
FAU - Kubow, S
AU  - Kubow S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 6158TKW0C5 (Phenytoin)
SB  - IM
MH  - *Abnormalities, Drug-Induced
MH  - Animal Feed
MH  - Animals
MH  - Body Weight
MH  - Fatty Acids, Omega-3/metabolism/*pharmacology
MH  - Fatty Acids, Unsaturated
MH  - Female
MH  - Food, Formulated
MH  - Gestational Age
MH  - Liver/chemistry
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Phenytoin/*pharmacology
MH  - Pregnancy
MH  - Pregnancy Outcome
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1007/BF02536699 [doi]
PST - ppublish
SO  - Lipids. 1994 Nov;29(11):771-8. doi: 10.1007/BF02536699.