PMID- 7869907
OWN - NLM
STAT- MEDLINE
DCOM- 19950328
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 44
IP  - 2
DP  - 1995 Feb
TI  - Interleukin-6 stimulates gluconeogenesis in primary cultures of rat hepatocytes.
PG  - 145-6
AB  - Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1 have been 
      shown to stimulate the synthesis of acute-phase proteins; however, few studies 
      have examined the effect of these cytokines on gluconeogenesis. We investigated 
      the effects of these cytokines on gluconeogenesis in primary cultures of rat 
      hepatocytes. Incubation of hepatocytes for 24 hours with TNF-alpha or IL-1 alpha 
      did not affect gluconeogenesis. Hepatocytes incubated with 100 pmol/L and 1 
      nmol/L IL-6 had a dose-dependent increase (P < .05) in gluconeogenesis (2.6 +/- 
      0.1 and 3.2 +/- 0.1 pmol/10(6) cells/min, respectively) as compared with controls 
      (2.0 +/- 0.1).
FAU - Blumberg, D
AU  - Blumberg D
AD  - Surgical Metabolism Laboratory, Memorial Sloan Kettering Cancer Center, New York, 
      NY 10021.
FAU - Hochwald, S
AU  - Hochwald S
FAU - Brennan, M F
AU  - Brennan MF
FAU - Burt, M
AU  - Burt M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Culture Media)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Culture Media
MH  - Glucose/*biosynthesis
MH  - Interleukin-1/pharmacology
MH  - Interleukin-6/*pharmacology
MH  - Liver/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred F344
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 0026-0495(95)90255-4 [pii]
AID - 10.1016/0026-0495(95)90255-4 [doi]
PST - ppublish
SO  - Metabolism. 1995 Feb;44(2):145-6. doi: 10.1016/0026-0495(95)90255-4.