PMID- 7869935
OWN - NLM
STAT- MEDLINE
DCOM- 19950329
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 44
IP  - 2 Suppl 2
DP  - 1995 Feb
TI  - Serotonin and dietary fat intake: effects of dexfenfluramine.
PG  - 33-7
AB  - Traditionally, serotonin (5-HT) has been most commonly linked with carbohydrate 
      (CHO) intake. However, in recent years it has been demonstrated that 
      serotoninergic drugs such as dexfenfluramine also reduce energy intake and 
      reverse body weight gain in rats exposed to weight-increasing high-fat diets. 
      Dexfenfluramine is also effective in decreasing food intake and body weight gain 
      of rats that gain weight on a high-fat cafeteria diet. The basic science studies 
      indicate that serotoninergic activity--induced by dexfenfluramine--can act as a 
      sufficient stimulus for the reduction of fat consumption. High-fat diets do not 
      appear to impede the suppressive effect of dexfenfluramine on food intake. In 
      human studies with dexfenfluramine, it has often been the case that the fat 
      content of test foods has been held constant--with only protein and CHO allowed 
      to vary. These studies therefore cannot display any direct effect on fat. 
      However, when food choice is not limited by experimental constraints, a 
      significant reduction of fat intake by dexfenfluramine has been demonstrated in 
      obese patients. In other experimental studies, dexfenfluramine has suppressed fat 
      intake to a greater extent than other macronutrients when free selection of foods 
      has been permitted. Taken together, these studies demonstrate that 
      dexfenfluramine is effective at reducing energy intake with a diet high in fat 
      and may under certain conditions cause a selective avoidance of high-fat foods.
FAU - Blundell, J E
AU  - Blundell JE
AD  - Psychology Department, University of Leeds, United Kingdom.
FAU - Lawton, C L
AU  - Lawton CL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Dietary Fats)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Dietary Fats/*administration & dosage
MH  - Energy Intake/drug effects
MH  - Fenfluramine/*pharmacology
MH  - Humans
MH  - Serotonin/*physiology
RF  - 54
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 0026-0495(95)90207-4 [pii]
AID - 10.1016/0026-0495(95)90207-4 [doi]
PST - ppublish
SO  - Metabolism. 1995 Feb;44(2 Suppl 2):33-7. doi: 10.1016/0026-0495(95)90207-4.