PMID- 7870894
OWN - NLM
STAT- MEDLINE
DCOM- 19950329
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 110
IP  - 1-2
DP  - 1993
TI  - Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor 
      activation in mice.
PG  - 254-6
AB  - The Straub tail reaction (STR) induced by intracerebroventricular injection (ICV) 
      of morphine was significantly antagonized by beta-funaltrexamine (beta-FNA, mu 
      antagonist), given intracerebroventricularly (ICV), but not naltrindole given ICV 
      (NTI, delta antagonist) or SC norbinaltorphimine given subcutaneously (SC) 
      (nor-BNI, kappa antagonist). When given either SC or ICV the kappa-agonist, 
      U-50,488 H markedly suppressed the STR elicited by ICV morphine; these effects 
      were reversed by nor-BNI. These results suggest that the activation of 
      supraspinal kappa receptors can inhibit the ICV morphine-induced STR which 
      results from activation of supraspinal mu receptors.
FAU - Narita, M
AU  - Narita M
AD  - Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
FAU - Suzuki, T
AU  - Suzuki T
FAU - Misawa, M
AU  - Misawa M
FAU - Nagase, H
AU  - Nagase H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Analgesics)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Pyrrolidines)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 36OOQ86QM1 (norbinaltorphimine)
RN  - 5S6W795CQM (Naltrexone)
RN  - 67198-13-4 
      (3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, 
      (trans)-Isomer)
RN  - 72782-05-9 (beta-funaltrexamine)
RN  - 76I7G6D29C (Morphine)
RN  - G167Z38QA4 (naltrindole)
SB  - IM
MH  - 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, 
      (trans)-Isomer
MH  - Analgesics/pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Morphine/administration & dosage/*antagonists & inhibitors/pharmacology
MH  - Naltrexone/analogs & derivatives/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Pain Measurement/*drug effects
MH  - Pyrrolidines/pharmacology
MH  - Receptors, Opioid, kappa/*agonists
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1007/BF02246982 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1993;110(1-2):254-6. doi: 10.1007/BF02246982.