PMID- 7871076
OWN - NLM
STAT- MEDLINE
DCOM- 19950324
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 115
IP  - 3
DP  - 1994 Jul
TI  - Psychomotor stimulant effects of d-amphetamine, MDMA and PCP: aggressive and 
      schedule-controlled behavior in mice.
PG  - 358-65
AB  - The objective of the present experiments was to characterize psychomotor 
      stimulant effects of d-amphetamine, methylenedioxymethamphetamine (MDMA) and 
      phencyclidine (PCP) on conditioned performance and on aggressive behavior in 
      mice. In a novel protocol with alternating periods of schedule-controlled 
      responding and aggressive behavior toward an intruder it was possible to assess a 
      range of species-specific agonistic acts, postures, and motor activities as well 
      as response rates and patterns engendered by a multiple Fixed Interval (FI) and 
      Fixed Ratio (FR) schedule within the same animal. Initially, it was confirmed 
      that d-amphetamine and, less reliably, MDMA and PCP, increased FI, but not FR 
      responding in mice. In the next experiment, mice confronted an intruder at the 
      midpoint of the 1-h daily session; following the display of aggressive behavior, 
      the rate of FI responding showed an amphetamine-like increase, whereas only a 
      transient change occurred after non-aggressive encounters. Thirdly, using this 
      new protocol, PCP, d-amphetamine and MDMA altered FI and FR responding in a way 
      that was closely similar to the first experiment. Low PCP and d-amphetamine doses 
      increased aggressive behavior erratically in certain individuals, but not 
      reliably for the group. MDMA dose-dependently decreased aggressive behavior, and 
      all drugs disrupted aggressive behavior at higher doses. The characteristic 
      increases in walking and decreases in rearing after higher doses of PCP and 
      d-amphetamine were greatly attenuated when the intruder was present.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Miczek, K A
AU  - Miczek KA
AD  - Department of Psychology, Tufts University, Medford, MA 02155.
FAU - Haney, M
AU  - Haney M
LA  - eng
GR  - AA05122/AA/NIAAA NIH HHS/United States
GR  - DA02632/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Central Nervous System Stimulants)
RN  - J1DOI7UV76 (Phencyclidine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Aggression/*drug effects
MH  - Animals
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Conditioning, Operant/*drug effects
MH  - Dextroamphetamine/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Mice
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Phencyclidine/*pharmacology
MH  - Reinforcement Schedule
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1007/BF02245077 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1994 Jul;115(3):358-65. doi: 10.1007/BF02245077.