PMID- 7880705
OWN - NLM
STAT- MEDLINE
DCOM- 19950411
LR  - 20190515
IS  - 0007-0912 (Print)
IS  - 0007-0912 (Linking)
VI  - 74
IP  - 1
DP  - 1995 Jan
TI  - Propofol pharmacokinetics in children with biliary atresia.
PG  - 46-9
AB  - We studied the pharmacokinetics of an i.v. bolus dose of propofol 2.5-3.0 mg kg-1 
      in eight children (age 4-24 months) with biliary atresia and in six control (ASA 
      I) children (age 11-43 months). Blood samples were obtained for 4 h after 
      administration of propofol. Blood concentrations of propofol were measured by 
      high pressure liquid chromatography. Systemic clearance of propofol (CI) and 
      volume of distribution at steady state (Vss) showed a highly significant 
      correlation with body weight. Propofol CI and Vss, normalized for body weight, 
      were similar in children with biliary atresia (mean 37.5 (SD 8.3) ml min-1 kg-1 
      and 3.5 (1.6) litre kg-1, respectively) compared with control children (38.7 
      (6.8) ml min-1 kg-1 and 2.4 (0.8) litre-1 kg-1, respectively). We conclude that 
      in children with biliary atresia the pharmacokinetics of propofol are similar to 
      those of healthy children.
FAU - Raoof, A A
AU  - Raoof AA
AD  - School of Pharmacy, Brussels, Belgium.
FAU - van Obbergh, L J
AU  - van Obbergh LJ
FAU - Verbeeck, R K
AU  - Verbeeck RK
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Biliary Atresia/*metabolism
MH  - Body Weight
MH  - Child, Preschool
MH  - Endoscopy
MH  - Humans
MH  - Infant
MH  - Liver/*metabolism
MH  - Metabolic Clearance Rate
MH  - Propofol/blood/*pharmacokinetics
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - S0007-0912(17)40794-X [pii]
AID - 10.1093/bja/74.1.46 [doi]
PST - ppublish
SO  - Br J Anaesth. 1995 Jan;74(1):46-9. doi: 10.1093/bja/74.1.46.