PMID- 7882301
OWN - NLM
STAT- MEDLINE
DCOM- 19950410
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 89
IP  - 1
DP  - 1995 Feb 10
TI  - Positive correlation of plasma transforming growth factor-beta 1 levels with 
      tumor vascularity in hepatocellular carcinoma.
PG  - 45-8
AB  - Transforming growth factor-beta 1 (TGF-beta 1) has been implicated in tumor 
      progression by promoting angiogenesis or suppressing immune system. We reported 
      previously that transforming growth factor-beta 1 (TGF-beta 1) is overproduced by 
      human hepatocellular carcinoma (HCC) tissues and that plasma TGF-beta 1 levels 
      are elevated in patients with HCC. In the present study, we investigated the 
      relationship between plasma TGF-beta 1 levels and tumor vascularity as assessed 
      by conventional celiac angiography in 17 patients with HCC. The plasma TGF-beta 1 
      level did not correlate with tumor size or underlying liver disease. However, we 
      found that plasma TGF-beta 1 levels correlated positively with the tumor 
      vascularity. These results suggest that excessive TGF-beta 1 production may 
      contribute to tumor angiogenesis in HCC.
FAU - Ito, N
AU  - Ito N
AD  - Second Department of Internal Medicine, Osaka, University Medical School, Japan.
FAU - Kawata, S
AU  - Kawata S
FAU - Tamura, S
AU  - Tamura S
FAU - Shirai, Y
AU  - Shirai Y
FAU - Kiso, S
AU  - Kiso S
FAU - Tsushima, H
AU  - Tsushima H
FAU - Matsuzawa, Y
AU  - Matsuzawa Y
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Aged
MH  - Angiography
MH  - Carcinoma, Hepatocellular/*blood/*blood supply
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*blood/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Transforming Growth Factor beta/*blood
EDAT- 1995/02/10 00:00
MHDA- 1995/02/10 00:01
CRDT- 1995/02/10 00:00
PHST- 1995/02/10 00:00 [pubmed]
PHST- 1995/02/10 00:01 [medline]
PHST- 1995/02/10 00:00 [entrez]
AID - 0304-3835(95)90156-6 [pii]
AID - 10.1016/0304-3835(95)90156-6 [doi]
PST - ppublish
SO  - Cancer Lett. 1995 Feb 10;89(1):45-8. doi: 10.1016/0304-3835(95)90156-6.