PMID- 7883226
OWN - NLM
STAT- MEDLINE
DCOM- 19950410
LR  - 20190501
IS  - 0017-5749 (Print)
IS  - 1458-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 36
IP  - 2
DP  - 1995 Feb
TI  - 1,25-Dihydroxyvitamin D3 and retinoid X receptor expression in human colorectal 
      neoplasms.
PG  - 255-8
AB  - Epidemiological studies suggest that 1,25-dihydroxyvitamin D3 (D3) protects 
      against colorectal carcinogenesis. Animal and in vitro studies show an 
      antiproliferative effect of D3 in a variety of tumours including those of large 
      bowel origin. D3 actions are mediated by D3 receptors (VDR) alone or by VDR in 
      conjunction with retinoid X receptors (RXRs) in all D3 responsive tissues. The 
      expression of mRNAs encoding VDR and RXRs in normal and malignant human 
      colorectum was determined. Full length VDR (4.6 kB), RXR alpha (5.5 kB), and RXR 
      gamma (3.5 and 7 kB) mRNAs were expressed in all tissues, but RXR beta mRNA was 
      not expressed in any. VDR expression was reduced in 12 carcinomas relative to 
      paired normal mucosa, and RXR alpha expression was reduced in nine. There was no 
      correlation between VDR or RXR alpha expression and the site, grade of 
      differentiation, or Dukes's staging of the tumour. The finding of persistent VDR 
      and RXR coexpression in all colorectal tumours provides a rational basis for 
      exploring a role for D3 in the treatment of colorectal malignancy.
FAU - Kane, K F
AU  - Kane KF
AD  - Department of Medicine, University of Birmingham, Edgbaston.
FAU - Langman, M J
AU  - Langman MJ
FAU - Williams, G R
AU  - Williams GR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Blotting, Northern
MH  - Calcitriol/analysis
MH  - Colorectal Neoplasms/*chemistry
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Nuclear Proteins/analysis
MH  - RNA, Messenger/*analysis
MH  - Receptors, Calcitriol/*analysis
MH  - Receptors, Retinoic Acid/*analysis
MH  - Retinoid X Receptors
MH  - Transcription Factors/*analysis
PMC - PMC1382413
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
PMCR- 1995/02/01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
PHST- 1995/02/01 00:00 [pmc-release]
AID - 10.1136/gut.36.2.255 [doi]
PST - ppublish
SO  - Gut. 1995 Feb;36(2):255-8. doi: 10.1136/gut.36.2.255.