PMID- 7884405
OWN - NLM
STAT- MEDLINE
DCOM- 19950413
LR  - 20161123
IS  - 0303-6995 (Print)
IS  - 0303-6995 (Linking)
VI  - 43
DP  - 1994
TI  - Neuroprotective effects of TGF-beta 1.
PG  - 33-45
AB  - The transforming growth factor-beta 1 (TGF-beta 1) has been shown to be an 
      injury-related peptide growth factor within the mammalian brain. We tested 
      TGF-beta 1 for its protective effects against neuronal degeneration caused by 
      sodium cyanide (1 mM) or by the excitatory amino acid L-glutamate (1 mM) in vitro 
      and against ischemic injury in vivo caused by permanent occlusion of the left 
      middle cerebral artery in mice. In vitro, TGF-beta 1 (1-30 ng/ml) significantly 
      reduced hypoxic and excitotoxic neuronal damage in a concentration-dependent 
      manner. In vivo, intracerebroventricular administration of TGF-beta 1 (1 
      microgram/kg) decreased the infarcted area on the mouse brain surface. The 
      present results suggest that TGF-beta 1 is capable of protecting neurons against 
      damage both in vitro and in vivo.
FAU - Henrich-Noack, P
AU  - Henrich-Noack P
AD  - Institut fur Pharmakologie und Toxikologie, Philipps-Universitat, Marburg, 
      Federal Republic of Germany.
FAU - Prehn, J H
AU  - Prehn JH
FAU - Krieglstein, J
AU  - Krieglstein J
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - J Neural Transm Suppl
JT  - Journal of neural transmission. Supplementum
JID - 0425126
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Transforming Growth Factor beta)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/pathology
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology/drug effects
MH  - Chick Embryo
MH  - Glutamic Acid/toxicity
MH  - Hypoxia/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Nerve Degeneration/drug effects
MH  - Neurons/drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Telencephalon/drug effects
MH  - Transforming Growth Factor beta/*pharmacology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - J Neural Transm Suppl. 1994;43:33-45.