PMID- 7885718
OWN - NLM
STAT- MEDLINE
DCOM- 19950411
LR  - 20031114
IS  - 0031-1758 (Print)
IS  - 0031-1758 (Linking)
VI  - 32
IP  - 11
DP  - 1994 Nov
TI  - Changes in choline acetyltransferase distribution in the cervical spinal cord 
      after reversible cervical spinal cord injury.
PG  - 752-8
AB  - Reversible spinal cord injury (SCI) at C6 level in rats, produced by the 
      weight-placed method, resulted in a severe motor functional deficit initially, 
      followed by a gradual recovery. During the recovery, choline acetyltransferase 
      (CAT) distribution in the cervical spinal cord was investigated at 2, 4, 7, 14 
      and 28 days after the injury by quantitative immunohistochemistry with a 
      fluorescence microphotometry system. At C6 level, the fluorescence intensity of 
      the ventrolateral anterior horn (VLAH), which reflected the concentration of CAT, 
      decreased to approximately 50% of that of the sham-operated group at 2 days. It 
      then recovered to 60% at 4 days after the injury, and remained unchanged 
      thereafter. Fluorescence intensities in VLAH at C4-5 and C7-8 levels decreased to 
      approximately 60-70% at 2 days after the injury, but it recovered and increased 
      to 110-130% thereafter.
FAU - Nakamura, M
AU  - Nakamura M
AD  - Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, 
      Japan.
FAU - Fujimura, Y
AU  - Fujimura Y
FAU - Yato, Y
AU  - Yato Y
FAU - Watanabe, M
AU  - Watanabe M
FAU - Iwamoto, Y
AU  - Iwamoto Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Paraplegia
JT  - Paraplegia
JID - 2985038R
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Choline O-Acetyltransferase/*metabolism
MH  - Fluorescent Antibody Technique
MH  - Immunohistochemistry
MH  - Microscopy, Fluorescence
MH  - Rats
MH  - Spinal Cord/*enzymology
MH  - Spinal Cord Injuries/*enzymology/pathology/physiopathology
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1038/sc.1994.121 [doi]
PST - ppublish
SO  - Paraplegia. 1994 Nov;32(11):752-8. doi: 10.1038/sc.1994.121.